tetano
Editor, Senior Moderator
Int J Infect Dis
. 2021 Feb 9;S1201-9712(21)00106-5.
doi: 10.1016/j.ijid.2021.02.021. Online ahead of print.
Epidemiological and clinical characteristics of 214 families with COVID-19 in Wuhan, China
Bo Yi[SUP] 1 [/SUP], Gaoke Fen[SUP] 2 [/SUP], Dedong Cao[SUP] 3 [/SUP], Yuli Cai[SUP] 4 [/SUP], Li Qian[SUP] 5 [/SUP], Wei Li[SUP] 5 [/SUP], Zhongyuan Wen[SUP] 6 [/SUP], Xuan Sun[SUP] 7 [/SUP]
Affiliations
Abstract
Objective: To investigated the epidemiological dynamics, transmission patterns and the clinical outcomes of Coronavirus disease 2019 (COVID-19) in familial cluster patients in Wuhan, China.
Methods: Between January 22, 2020 and February 4, 2020, we enrolled 214 families for this retrospective study. The COVID-19 cases were diagnosed using Real-time reverse-transcriptase polymerase chain reaction (RT-PCR). Number of COVID-19 subjects in a family, their relationship with index patients, the key time-to-event, exposure history, and the clinical outcomes were obtained through telephone calls.
Results: Overall 96 families (44.9%) met the criteria of a familial cluster, which is at least one confirmed case in addition to the index patient in the same household. The secondary attack rate was 42.9%, and nearly 95% of index patients transmitted the infection to ≤2 other family members. High transmission pattern was noted between couples (51.0%) and among multi-generations (27.1%). The median serial interval distribution in familial clusters was 5 days (95% CI, 4 to 6). The case fatality rate was 8.7% in index patients and 1.7% in non-familial clusters patients (p = 0.023).
Conclusions: There is an related higher attack rate and the worse clinical outcomes in COVID-19 family clusters.
Keywords: COVID-19; epidemiological dynamics; household transmission; transmission patterns.
. 2021 Feb 9;S1201-9712(21)00106-5.
doi: 10.1016/j.ijid.2021.02.021. Online ahead of print.
Epidemiological and clinical characteristics of 214 families with COVID-19 in Wuhan, China
Bo Yi[SUP] 1 [/SUP], Gaoke Fen[SUP] 2 [/SUP], Dedong Cao[SUP] 3 [/SUP], Yuli Cai[SUP] 4 [/SUP], Li Qian[SUP] 5 [/SUP], Wei Li[SUP] 5 [/SUP], Zhongyuan Wen[SUP] 6 [/SUP], Xuan Sun[SUP] 7 [/SUP]
Affiliations
- PMID: 33578019
- PMCID: PMC7872852
- DOI: 10.1016/j.ijid.2021.02.021
Abstract
Objective: To investigated the epidemiological dynamics, transmission patterns and the clinical outcomes of Coronavirus disease 2019 (COVID-19) in familial cluster patients in Wuhan, China.
Methods: Between January 22, 2020 and February 4, 2020, we enrolled 214 families for this retrospective study. The COVID-19 cases were diagnosed using Real-time reverse-transcriptase polymerase chain reaction (RT-PCR). Number of COVID-19 subjects in a family, their relationship with index patients, the key time-to-event, exposure history, and the clinical outcomes were obtained through telephone calls.
Results: Overall 96 families (44.9%) met the criteria of a familial cluster, which is at least one confirmed case in addition to the index patient in the same household. The secondary attack rate was 42.9%, and nearly 95% of index patients transmitted the infection to ≤2 other family members. High transmission pattern was noted between couples (51.0%) and among multi-generations (27.1%). The median serial interval distribution in familial clusters was 5 days (95% CI, 4 to 6). The case fatality rate was 8.7% in index patients and 1.7% in non-familial clusters patients (p = 0.023).
Conclusions: There is an related higher attack rate and the worse clinical outcomes in COVID-19 family clusters.
Keywords: COVID-19; epidemiological dynamics; household transmission; transmission patterns.