tetano
Editor, Senior Moderator
Int J Infect Dis. 2015 Sep 25. pii: S1201-9712(15)00223-4. doi: 10.1016/j.ijid.2015.09.013. [Epub ahead of print]
[h=1]Interim estimates of divergence date and vaccine strain match of human influenza A(H3N2) virus from systematic influenza surveillance (2010-2015) in Hangzhou, southeast of China.[/h] Li J[SUP]1[/SUP], Zhou YY[SUP]2[/SUP], Kou Y[SUP]2[/SUP], Yu XF[SUP]2[/SUP], Zheng ZB[SUP]2[/SUP], Yang XH[SUP]3[/SUP], Wang HQ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] In the post-pandemic period 2010-2015, seasonal influenza A(H3N2) virus prevailed predominantly in Hangzhou, southeast of China, with an increased activity and its semi-annual seasons. This study utilized the sequences of HA virus gene segments to analyze the divergence date and vaccine strain match of human influenza A(H3N2) virus from systematic influenza surveillance in Hangzhou.
[h=4]METHODS:[/h] The virological and serological analysis of 124 representative A(H3N2) viruses from prospective studies of systematic surveillance samples were conducted to quantify the genetic and antigenic characteristics and their vaccine strain match.
[h=4]RESULTS:[/h] Bayesian phylogenetic inference showed that two separate subgroup 3C.3 and 3C.2 probably diverged from the group 3C in the early 2012, and then evolved to group 3C.3a and 3C.2a respectively in the 2014/15 influenza season. Furthermore, high amino acid substitution rates of the HA1 subunit were found in A(H3N2) group 3C.2a variants, indicating that increased antigenic drift of A(H3N2) group 3C.2a virus is associated with the vaccine mismatch to the 2015/16 vaccine reference strain Switzerland/9715293/2013 (group 3C.3a).
[h=4]CONCLUSIONS:[/h] A portion of the group 3C.2a isolates are not covered by the current A(H3N2) vaccine strain. Our findings offer insights into the emergence of group 3C.2a variants with epidemic potential in the imminent influenza seasons.
Copyright ? 2015. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Antigenic drift; Divergence; H3N2; Influenza A; Vaccine match
PMID: 26417878 [PubMed - as supplied by publisher]
[h=1]Interim estimates of divergence date and vaccine strain match of human influenza A(H3N2) virus from systematic influenza surveillance (2010-2015) in Hangzhou, southeast of China.[/h] Li J[SUP]1[/SUP], Zhou YY[SUP]2[/SUP], Kou Y[SUP]2[/SUP], Yu XF[SUP]2[/SUP], Zheng ZB[SUP]2[/SUP], Yang XH[SUP]3[/SUP], Wang HQ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] In the post-pandemic period 2010-2015, seasonal influenza A(H3N2) virus prevailed predominantly in Hangzhou, southeast of China, with an increased activity and its semi-annual seasons. This study utilized the sequences of HA virus gene segments to analyze the divergence date and vaccine strain match of human influenza A(H3N2) virus from systematic influenza surveillance in Hangzhou.
[h=4]METHODS:[/h] The virological and serological analysis of 124 representative A(H3N2) viruses from prospective studies of systematic surveillance samples were conducted to quantify the genetic and antigenic characteristics and their vaccine strain match.
[h=4]RESULTS:[/h] Bayesian phylogenetic inference showed that two separate subgroup 3C.3 and 3C.2 probably diverged from the group 3C in the early 2012, and then evolved to group 3C.3a and 3C.2a respectively in the 2014/15 influenza season. Furthermore, high amino acid substitution rates of the HA1 subunit were found in A(H3N2) group 3C.2a variants, indicating that increased antigenic drift of A(H3N2) group 3C.2a virus is associated with the vaccine mismatch to the 2015/16 vaccine reference strain Switzerland/9715293/2013 (group 3C.3a).
[h=4]CONCLUSIONS:[/h] A portion of the group 3C.2a isolates are not covered by the current A(H3N2) vaccine strain. Our findings offer insights into the emergence of group 3C.2a variants with epidemic potential in the imminent influenza seasons.
Copyright ? 2015. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Antigenic drift; Divergence; H3N2; Influenza A; Vaccine match
PMID: 26417878 [PubMed - as supplied by publisher]