tetano
Editor, Senior Moderator
Intern Emerg Med
. 2022 Apr 23.
doi: 10.1007/s11739-022-02981-3. Online ahead of print.
Correlation of SpO [SUB]2[/SUB]/FiO [SUB]2[/SUB] and PaO [SUB]2[/SUB]/FiO [SUB]2[/SUB] in patients with symptomatic COVID-19: An observational, retrospective study
Aldo Bonaventura[SUP] #[/SUP][SUP] 1 [/SUP], Nicola Mumoli[SUP] #[/SUP][SUP] 2 [/SUP], Antonino Mazzone[SUP] 3 [/SUP], Alessandra Colombo[SUP] 2 [/SUP], Isabella Evangelista[SUP] 2 [/SUP], Scilla Cerutti[SUP] 2 [/SUP], Lorenza Brivio[SUP] 3 [/SUP], Alessandra Vecchié[SUP] 4 [/SUP], Alice Bonomi[SUP] 5 [/SUP], Ombretta Para[SUP] 6 [/SUP], Annamaria Bellizzi[SUP] 7 [/SUP], Marco Cei[SUP] 8 [/SUP], Patrizia Fenu[SUP] 8 [/SUP], Flavio Tangianu[SUP] 4 [/SUP], Francesco Dentali[SUP] 9 [/SUP], Francesco Cei[SUP] 10 [/SUP]
Affiliations
Abstract
Some patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) experience acute hypoxemic respiratory failure progressing toward atypical acute respiratory distress syndrome (ARDS). The aim of the study is to evaluate whether a correlation between ratio of peripheral saturation of oxygen (SpO[SUB]2[/SUB]) and fraction of inspired oxygen (S/F) and ratio of arterial partial pressure of oxygen and fraction of inspired oxygen (P/F) exists in COVID-19-related ARDS as already known in classical ARDS. In this multicenter, retrospective, observational study, consecutive, adult (≥ 18 years) patients with symptomatic coronavirus disease 2019 (COVID-19) admitted to different COVID-19 divisions in Italy between March and December 2020 were included. Patients with SpO[SUB]2[/SUB] > 97% or missing information were excluded. We included 1,028 patients (median age 72 years, prevalence of males [62.2%]). A positive correlation was found between P/F and S/F (r = 0.938, p < 0.0001). A receiver operating characteristic (ROC) curve analysis showed that S/F accurately recognizes the presence of ARDS (P/F ≤ 300 mmHg) in COVID-19 patients, with a cut-off of ≤ 433% showing good sensitivity and specificity. S/F was also tested against P/F values ≤ 200 and ≤ 100 mmHg (suggestive for moderate and severe ARDS, respectively), the latter showing great accuracy for S/F ≤ 178%. S/F was accurate in predicting ARDS for SpO[SUB]2[/SUB] ≥ 92%. In conclusion, our findings support the routine use of S/F as a reliable surrogate of P/F in patients with COVID-19-related ARDS.
Keywords: ARDS; COVID-19; Cytokine storm; Diagnosis; Respiratory failure; SARS-CoV-2.
. 2022 Apr 23.
doi: 10.1007/s11739-022-02981-3. Online ahead of print.
Correlation of SpO [SUB]2[/SUB]/FiO [SUB]2[/SUB] and PaO [SUB]2[/SUB]/FiO [SUB]2[/SUB] in patients with symptomatic COVID-19: An observational, retrospective study
Aldo Bonaventura[SUP] #[/SUP][SUP] 1 [/SUP], Nicola Mumoli[SUP] #[/SUP][SUP] 2 [/SUP], Antonino Mazzone[SUP] 3 [/SUP], Alessandra Colombo[SUP] 2 [/SUP], Isabella Evangelista[SUP] 2 [/SUP], Scilla Cerutti[SUP] 2 [/SUP], Lorenza Brivio[SUP] 3 [/SUP], Alessandra Vecchié[SUP] 4 [/SUP], Alice Bonomi[SUP] 5 [/SUP], Ombretta Para[SUP] 6 [/SUP], Annamaria Bellizzi[SUP] 7 [/SUP], Marco Cei[SUP] 8 [/SUP], Patrizia Fenu[SUP] 8 [/SUP], Flavio Tangianu[SUP] 4 [/SUP], Francesco Dentali[SUP] 9 [/SUP], Francesco Cei[SUP] 10 [/SUP]
Affiliations
- PMID: 35460432
- DOI: 10.1007/s11739-022-02981-3
Abstract
Some patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) experience acute hypoxemic respiratory failure progressing toward atypical acute respiratory distress syndrome (ARDS). The aim of the study is to evaluate whether a correlation between ratio of peripheral saturation of oxygen (SpO[SUB]2[/SUB]) and fraction of inspired oxygen (S/F) and ratio of arterial partial pressure of oxygen and fraction of inspired oxygen (P/F) exists in COVID-19-related ARDS as already known in classical ARDS. In this multicenter, retrospective, observational study, consecutive, adult (≥ 18 years) patients with symptomatic coronavirus disease 2019 (COVID-19) admitted to different COVID-19 divisions in Italy between March and December 2020 were included. Patients with SpO[SUB]2[/SUB] > 97% or missing information were excluded. We included 1,028 patients (median age 72 years, prevalence of males [62.2%]). A positive correlation was found between P/F and S/F (r = 0.938, p < 0.0001). A receiver operating characteristic (ROC) curve analysis showed that S/F accurately recognizes the presence of ARDS (P/F ≤ 300 mmHg) in COVID-19 patients, with a cut-off of ≤ 433% showing good sensitivity and specificity. S/F was also tested against P/F values ≤ 200 and ≤ 100 mmHg (suggestive for moderate and severe ARDS, respectively), the latter showing great accuracy for S/F ≤ 178%. S/F was accurate in predicting ARDS for SpO[SUB]2[/SUB] ≥ 92%. In conclusion, our findings support the routine use of S/F as a reliable surrogate of P/F in patients with COVID-19-related ARDS.
Keywords: ARDS; COVID-19; Cytokine storm; Diagnosis; Respiratory failure; SARS-CoV-2.