tetano
Editor, Senior Moderator
Intern Med
. 2021 Oct 26.
doi: 10.2169/internalmedicine.8310-21. Online ahead of print.
COVID-19 mRNA Vaccine-induced Pneumonitis: A Case Report
Shinichi Matsuzaki[SUP] 1 [/SUP], Hiroyuki Kamiya[SUP] 1 [/SUP], Ichiro Inoshima[SUP] 1 [/SUP], Yasutaka Hirasawa[SUP] 2 [/SUP], Osamu Tago[SUP] 3 [/SUP], Masashi Arai[SUP] 4 [/SUP]
Affiliations
Abstract
A 65-year-old man experienced cough and shortness of breath 3 days after receiving the first dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) vaccine. Chest X-ray revealed bilateral infiltrates, and the desaturation deteriorated rapidly. The symptoms and radiographic abnormalities rapidly improved after the initiation of corticosteroid therapy. Intradermal testing of the Pfizer-BioNTech COVID-19 vaccine showed a delayed positive reaction. Based on these findings, the patient was diagnosed with COVID-19 vaccine-induced pneumonitis. The timing of the onset of pneumonitis after vaccination and the results of intradermal testing suggest that Type IV hypersensitivity against COVID-19 vaccine may have been responsible for this clinical condition.
Keywords: COVID-19; intradermal testing; mRNA vaccine; vaccine-induced pneumonitis.
. 2021 Oct 26.
doi: 10.2169/internalmedicine.8310-21. Online ahead of print.
COVID-19 mRNA Vaccine-induced Pneumonitis: A Case Report
Shinichi Matsuzaki[SUP] 1 [/SUP], Hiroyuki Kamiya[SUP] 1 [/SUP], Ichiro Inoshima[SUP] 1 [/SUP], Yasutaka Hirasawa[SUP] 2 [/SUP], Osamu Tago[SUP] 3 [/SUP], Masashi Arai[SUP] 4 [/SUP]
Affiliations
- PMID: 34707048
- DOI: 10.2169/internalmedicine.8310-21
Abstract
A 65-year-old man experienced cough and shortness of breath 3 days after receiving the first dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) vaccine. Chest X-ray revealed bilateral infiltrates, and the desaturation deteriorated rapidly. The symptoms and radiographic abnormalities rapidly improved after the initiation of corticosteroid therapy. Intradermal testing of the Pfizer-BioNTech COVID-19 vaccine showed a delayed positive reaction. Based on these findings, the patient was diagnosed with COVID-19 vaccine-induced pneumonitis. The timing of the onset of pneumonitis after vaccination and the results of intradermal testing suggest that Type IV hypersensitivity against COVID-19 vaccine may have been responsible for this clinical condition.
Keywords: COVID-19; intradermal testing; mRNA vaccine; vaccine-induced pneumonitis.