tetano
Editor, Senior Moderator
iScience
. 2021 Mar 9;102293.
doi: 10.1016/j.isci.2021.102293. Online ahead of print.
Title: ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway
Xiaoyuan Lin[SUP] 1 [/SUP], Beibei Fu[SUP] 1 [/SUP], Songna Yin[SUP] 2 [/SUP], Zhifeng Li[SUP] 3 [/SUP], Huawen Liu[SUP] 4 [/SUP], Haiwei Zhang[SUP] 5 [/SUP], Na Xing[SUP] 6 [/SUP], Yu Wang[SUP] 7 [/SUP], Weiwei Xue[SUP] 8 [/SUP], Yan Xiong[SUP] 1 [/SUP], Shanfu Zhang[SUP] 1 [/SUP], Qingting Zhao[SUP] 1 [/SUP], Shiyao Xu[SUP] 1 [/SUP], Jing Zhang[SUP] 9 [/SUP], Peihui Wang[SUP] 9 [/SUP], Weiqi Nian[SUP] 5 [/SUP], Xingsheng Wang[SUP] 10 [/SUP], Haibo Wu[SUP] 1 [/SUP]
Affiliations
Abstract
Recently, COVID-19 caused by the novel coronavirus SARS-CoV-2 has brought great challenges to the world. More and more studies have shown that severe patients may suffer from cytokine storm syndrome; however, there are few studies on its pathogenesis. Here we demonstrated that SARS-CoV-2 coding protein open reading frame 8 (ORF8) acted as a contributing factor to cytokine storm during COVID-19 infection. ORF8 could activate IL-17 signaling pathway and promote the expression of pro-inflammatory factors. Moreover, we demonstrated that treatment of IL17RA antibody protected mice from ORF8-induced inflammation. Our findings are helpful to understand the pathogenesis of cytokine storm caused by SARS-CoV-2, and provide a potential target for the development of COVID-19 therapeutic drugs.
Keywords: COVID-19; IL-17; SARS-CoV-2; cytokine storm; open reading frame 8.
. 2021 Mar 9;102293.
doi: 10.1016/j.isci.2021.102293. Online ahead of print.
Title: ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway
Xiaoyuan Lin[SUP] 1 [/SUP], Beibei Fu[SUP] 1 [/SUP], Songna Yin[SUP] 2 [/SUP], Zhifeng Li[SUP] 3 [/SUP], Huawen Liu[SUP] 4 [/SUP], Haiwei Zhang[SUP] 5 [/SUP], Na Xing[SUP] 6 [/SUP], Yu Wang[SUP] 7 [/SUP], Weiwei Xue[SUP] 8 [/SUP], Yan Xiong[SUP] 1 [/SUP], Shanfu Zhang[SUP] 1 [/SUP], Qingting Zhao[SUP] 1 [/SUP], Shiyao Xu[SUP] 1 [/SUP], Jing Zhang[SUP] 9 [/SUP], Peihui Wang[SUP] 9 [/SUP], Weiqi Nian[SUP] 5 [/SUP], Xingsheng Wang[SUP] 10 [/SUP], Haibo Wu[SUP] 1 [/SUP]
Affiliations
- PMID: 33723527
- PMCID: PMC7942160
- DOI: 10.1016/j.isci.2021.102293
Abstract
Recently, COVID-19 caused by the novel coronavirus SARS-CoV-2 has brought great challenges to the world. More and more studies have shown that severe patients may suffer from cytokine storm syndrome; however, there are few studies on its pathogenesis. Here we demonstrated that SARS-CoV-2 coding protein open reading frame 8 (ORF8) acted as a contributing factor to cytokine storm during COVID-19 infection. ORF8 could activate IL-17 signaling pathway and promote the expression of pro-inflammatory factors. Moreover, we demonstrated that treatment of IL17RA antibody protected mice from ORF8-induced inflammation. Our findings are helpful to understand the pathogenesis of cytokine storm caused by SARS-CoV-2, and provide a potential target for the development of COVID-19 therapeutic drugs.
Keywords: COVID-19; IL-17; SARS-CoV-2; cytokine storm; open reading frame 8.