tetano
Editor, Senior Moderator
Bioorg Med Chem Lett. 2017 Nov 15. pii: S0960-894X(17)31116-2. doi: 10.1016/j.bmcl.2017.11.029. [Epub ahead of print]
[h=1]Isosteric ribavirin analogues: Synthesis and antiviral activities.[/h] Zhurilo NI[SUP]1[/SUP], Chudinov MV[SUP]2[/SUP], Matveev AV[SUP]1[/SUP], Smirnova OS[SUP]3[/SUP], Konstantinova ID[SUP]3[/SUP], Miroshnikov AI[SUP]3[/SUP], Prutkov AN[SUP]4[/SUP], Grebenkina LE[SUP]4[/SUP], Pulkova NV[SUP]4[/SUP], Shvets VI[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant antiviral action against hepatitis C virus (HCV), herpes simplex (HCV-1) and influenza A virus comparable to that of ribavirin itself. The data obtained confirm the proposed theory of the ribavirin possible antiviral activity mechanism related with bioisosterism.
[h=4]KEYWORDS:[/h] Antivirals; Isosterism; Nucleoside analogues; Ribavirin
PMID: 29173944 DOI: 10.1016/j.bmcl.2017.11.029
[h=1]Isosteric ribavirin analogues: Synthesis and antiviral activities.[/h] Zhurilo NI[SUP]1[/SUP], Chudinov MV[SUP]2[/SUP], Matveev AV[SUP]1[/SUP], Smirnova OS[SUP]3[/SUP], Konstantinova ID[SUP]3[/SUP], Miroshnikov AI[SUP]3[/SUP], Prutkov AN[SUP]4[/SUP], Grebenkina LE[SUP]4[/SUP], Pulkova NV[SUP]4[/SUP], Shvets VI[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant antiviral action against hepatitis C virus (HCV), herpes simplex (HCV-1) and influenza A virus comparable to that of ribavirin itself. The data obtained confirm the proposed theory of the ribavirin possible antiviral activity mechanism related with bioisosterism.
[h=4]KEYWORDS:[/h] Antivirals; Isosterism; Nucleoside analogues; Ribavirin
PMID: 29173944 DOI: 10.1016/j.bmcl.2017.11.029