tetano
Editor, Senior Moderator
Isr Med Assoc J
. 2020 Aug;8(22):429-434.
Ferritin as a Marker of Severity in COVID-19 Patients: A Fatal Correlation
Shani Dahan[SUP] 1 2 [/SUP], Gad Segal[SUP] 3 2 [/SUP], Itai Katz[SUP] 4 2 [/SUP], Tamar Hellou[SUP] 1 [/SUP], Michal Tietel[SUP] 1 [/SUP], Gabriel Bryk[SUP] 5 [/SUP], Howard Amital[SUP] 6 4 [/SUP], Yehuda Shoenfeld[SUP] 4 2 [/SUP], Amir Dagan[SUP] 1 7 [/SUP]
Affiliations
Abstract
Background: Ferritin, the cellular protein storage for iron, has emerged as a key molecule in the immune system, orchestrating the cellular defense against inflammation. At the end of 2019, the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) rapidly spread throughout China and other countries around the world, resulting in a viral pandemic.
Objectives: To evaluate the correlation between ferritin and disease severity in coronavirus disease-2019 (COVID-19).
Methods: In this cross-sectional study, we obtained clinical and laboratory data regarding 39 hospitalized patients with confirmed COVID-19 from two hospitals in Israel.
Results: A significant increase in ferritin levels was demonstrated in patients with moderate and severe disease, compared to patients with mild disease (P = 0.006 and 0.005, respectively). Severe patients had significantly higher levels of ferritin (2817.6 ng/ml) than non-severe patients (708.6 ng/ml) P = 0.02.
Conclusions: In this preliminary cross-sectional study, elevated ferritin levels were shown to correlate with disease severity in 39 patients from Israel with confirmed COVID-19 infection. Our results further strengthen the hypothesis that severe COVID-19 disease might be due to an underlying dysregulated hyperimmune response. In order to identify these patients early and prioritized resources, we believe that all patients with COVID-19 should be screened for hyperferritinemia.
. 2020 Aug;8(22):429-434.
Ferritin as a Marker of Severity in COVID-19 Patients: A Fatal Correlation
Shani Dahan[SUP] 1 2 [/SUP], Gad Segal[SUP] 3 2 [/SUP], Itai Katz[SUP] 4 2 [/SUP], Tamar Hellou[SUP] 1 [/SUP], Michal Tietel[SUP] 1 [/SUP], Gabriel Bryk[SUP] 5 [/SUP], Howard Amital[SUP] 6 4 [/SUP], Yehuda Shoenfeld[SUP] 4 2 [/SUP], Amir Dagan[SUP] 1 7 [/SUP]
Affiliations
- PMID: 32812717
Abstract
Background: Ferritin, the cellular protein storage for iron, has emerged as a key molecule in the immune system, orchestrating the cellular defense against inflammation. At the end of 2019, the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) rapidly spread throughout China and other countries around the world, resulting in a viral pandemic.
Objectives: To evaluate the correlation between ferritin and disease severity in coronavirus disease-2019 (COVID-19).
Methods: In this cross-sectional study, we obtained clinical and laboratory data regarding 39 hospitalized patients with confirmed COVID-19 from two hospitals in Israel.
Results: A significant increase in ferritin levels was demonstrated in patients with moderate and severe disease, compared to patients with mild disease (P = 0.006 and 0.005, respectively). Severe patients had significantly higher levels of ferritin (2817.6 ng/ml) than non-severe patients (708.6 ng/ml) P = 0.02.
Conclusions: In this preliminary cross-sectional study, elevated ferritin levels were shown to correlate with disease severity in 39 patients from Israel with confirmed COVID-19 infection. Our results further strengthen the hypothesis that severe COVID-19 disease might be due to an underlying dysregulated hyperimmune response. In order to identify these patients early and prioritized resources, we believe that all patients with COVID-19 should be screened for hyperferritinemia.