tetano
Editor, Senior Moderator
J Cell Mol Med
. 2020 Aug 30.
doi: 10.1111/jcmm.15620. Online ahead of print.
The phenotypic changes of γδ T cells in COVID-19 patients
Lei Lei[SUP] 1 [/SUP], Hongbo Qian[SUP] 2 [/SUP], Xiaofang Yang[SUP] 1 [/SUP], Xingzhe Zhang[SUP] 1 [/SUP], Dan Zhang[SUP] 1 [/SUP], Tongxin Dai[SUP] 2 [/SUP], Rui Guo[SUP] 2 [/SUP], Lin Shi[SUP] 1 [/SUP], Yanbin Cheng[SUP] 1 [/SUP], Baojun Zhang[SUP] 1 [/SUP], Xiaobo Zhou[SUP] 1 3 4 [/SUP], Jinsong Hu[SUP] 5 [/SUP], Yaling Guo[SUP] 2 [/SUP]
Affiliations
Abstract
A novel pneumonia-associated respiratory syndrome named coronavirus disease-2019 (COVID-19), which was caused by SARS-CoV-2，broke out in Wuhan, China, in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARS-CoV-2 infections. The information regarding the immunological characteristics in COVID-19 patients remains limited. Here, we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes on γδ T cell population. In comparison with HD, the γδ T cell percentage decreased, while the activation marker CD25 expression increased in response to SARS-CoV-2 infection. Interestingly, the CD4 expression was upregulated in γδ T cells reflecting the occurrence of a specific effector cell population, which may serve as a biomarker for the assessment of SARS-CoV-2 infection.
Keywords: COVID-19; SARS-CoV-2; activation; innate immunity; γδ T cells.
. 2020 Aug 30.
doi: 10.1111/jcmm.15620. Online ahead of print.
The phenotypic changes of γδ T cells in COVID-19 patients
Lei Lei[SUP] 1 [/SUP], Hongbo Qian[SUP] 2 [/SUP], Xiaofang Yang[SUP] 1 [/SUP], Xingzhe Zhang[SUP] 1 [/SUP], Dan Zhang[SUP] 1 [/SUP], Tongxin Dai[SUP] 2 [/SUP], Rui Guo[SUP] 2 [/SUP], Lin Shi[SUP] 1 [/SUP], Yanbin Cheng[SUP] 1 [/SUP], Baojun Zhang[SUP] 1 [/SUP], Xiaobo Zhou[SUP] 1 3 4 [/SUP], Jinsong Hu[SUP] 5 [/SUP], Yaling Guo[SUP] 2 [/SUP]
Affiliations
- PMID: 32864865
- DOI: 10.1111/jcmm.15620
Abstract
A novel pneumonia-associated respiratory syndrome named coronavirus disease-2019 (COVID-19), which was caused by SARS-CoV-2，broke out in Wuhan, China, in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARS-CoV-2 infections. The information regarding the immunological characteristics in COVID-19 patients remains limited. Here, we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes on γδ T cell population. In comparison with HD, the γδ T cell percentage decreased, while the activation marker CD25 expression increased in response to SARS-CoV-2 infection. Interestingly, the CD4 expression was upregulated in γδ T cells reflecting the occurrence of a specific effector cell population, which may serve as a biomarker for the assessment of SARS-CoV-2 infection.
Keywords: COVID-19; SARS-CoV-2; activation; innate immunity; γδ T cells.