tetano
Editor, Senior Moderator
J Clin Virol
. 2020 Oct 18;133:104662.
doi: 10.1016/j.jcv.2020.104662. Online ahead of print.
Longitudinal course of influenza C virus antibody titers of healthy adults in Sendai, Japan
Feng Liao[SUP] 1 [/SUP], Hidekazu Nishimura[SUP] 2 [/SUP], Hiroko Ito[SUP] 2 [/SUP], Yunhui Zhang[SUP] 3 [/SUP], Yoko Matsuzaki[SUP] 4 [/SUP]
Affiliations
Abstract
Background: Influenza C virus causes mild respiratory diseases in humans. Previous studies suggested that the predominant hemagglutinin-esterase gene lineage circulating in children might be selected among the adult population, yet the prevalence of influenza C virus in adults has not been described.
Objectives: To evaluate the frequency of influenza C virus infection in adults.
Study design: We performed hemagglutination inhibition assays of serum samples collected at periodic occupational medical checkups from employees of a hospital. A total of 679 serum samples were collected from 57 subjects who participated in biannual medical checkups between 2011 and 2016 as part of a longitudinal series. Titers of antibodies against the C/Kanagawa and C/Sao Paulo lineage viruses were detected.
Results: Ten serum sample pairs from among the 57 subjects showed at least a four-fold increase in influenza C antibody titers. Samples from three subjects exhibited antibody titer increases for both the C/Kanagawa and C/Sao Paulo lineages, four subjects showed an increased titer against the C/Sao Paulo lineage, and three subjects showed an increased titer against the C/Kanagawa lineage. Half of the antibody titer increases for the C/Kanagawa lineage were detected in May 2014, while the increases for the C/Sao Paulo lineage were detected from 2011 to 2016.
Conclusion: The 5-year influenza C virus infection rate was estimated at 17.5 %. There were antibodies that cross-reacted with the C/Sao Paulo and C/Kanagawa lineages. The results suggest that C/Sao Paulo was the main lineage in the adult population of this area, with cocirculation of the C/Kanagawa lineage.
Keywords: Adults; Hemagglutination inhibition assay; Immunity; Influenza C; Seroprevalence.
. 2020 Oct 18;133:104662.
doi: 10.1016/j.jcv.2020.104662. Online ahead of print.
Longitudinal course of influenza C virus antibody titers of healthy adults in Sendai, Japan
Feng Liao[SUP] 1 [/SUP], Hidekazu Nishimura[SUP] 2 [/SUP], Hiroko Ito[SUP] 2 [/SUP], Yunhui Zhang[SUP] 3 [/SUP], Yoko Matsuzaki[SUP] 4 [/SUP]
Affiliations
- PMID: 33137705
- DOI: 10.1016/j.jcv.2020.104662
Abstract
Background: Influenza C virus causes mild respiratory diseases in humans. Previous studies suggested that the predominant hemagglutinin-esterase gene lineage circulating in children might be selected among the adult population, yet the prevalence of influenza C virus in adults has not been described.
Objectives: To evaluate the frequency of influenza C virus infection in adults.
Study design: We performed hemagglutination inhibition assays of serum samples collected at periodic occupational medical checkups from employees of a hospital. A total of 679 serum samples were collected from 57 subjects who participated in biannual medical checkups between 2011 and 2016 as part of a longitudinal series. Titers of antibodies against the C/Kanagawa and C/Sao Paulo lineage viruses were detected.
Results: Ten serum sample pairs from among the 57 subjects showed at least a four-fold increase in influenza C antibody titers. Samples from three subjects exhibited antibody titer increases for both the C/Kanagawa and C/Sao Paulo lineages, four subjects showed an increased titer against the C/Sao Paulo lineage, and three subjects showed an increased titer against the C/Kanagawa lineage. Half of the antibody titer increases for the C/Kanagawa lineage were detected in May 2014, while the increases for the C/Sao Paulo lineage were detected from 2011 to 2016.
Conclusion: The 5-year influenza C virus infection rate was estimated at 17.5 %. There were antibodies that cross-reacted with the C/Sao Paulo and C/Kanagawa lineages. The results suggest that C/Sao Paulo was the main lineage in the adult population of this area, with cocirculation of the C/Kanagawa lineage.
Keywords: Adults; Hemagglutination inhibition assay; Immunity; Influenza C; Seroprevalence.