tetano
Editor, Senior Moderator
J Crit Care
. 2022 Oct 6;72:154164.
doi: 10.1016/j.jcrc.2022.154164. Online ahead of print.
The impacts of bacterial co-infections and secondary bacterial infections on patients with severe influenza pneumonitis admitted to the intensive care units
Wei-Chun Lee[SUP] 1 [/SUP], Meng-Chin Ho[SUP] 1 [/SUP], Shaw-Woei Leu[SUP] 2 [/SUP], Che-Chia Chang[SUP] 1 [/SUP], Chin-Kuo Lin[SUP] 1 [/SUP], Chieh-Mo Lin[SUP] 1 [/SUP], Yu-Hung Fang[SUP] 1 [/SUP], Shu-Yi Huang[SUP] 1 [/SUP], Yu-Ching Lin[SUP] 3 [/SUP], Min-Chun Chuang[SUP] 1 [/SUP], Tsung-Ming Yang[SUP] 1 [/SUP], Ming-Szu Hung[SUP] 3 [/SUP], Yen-Li Chou[SUP] 1 [/SUP], Ying-Huang Tsai[SUP] 4 [/SUP], Meng-Jer Hsieh[SUP] 5 [/SUP]
Affiliations
Abstract
Purposes: This study investigated the prevalence and clinical outcomes of pulmonary bacterial co-infections and secondary bacterial infections in patients with severe influenza pneumonitis.
Methods: We retrospectively analyzed the data of adult patients with severe influenza pneumonitis admitted to medical ICUs. Bacterial co-infections and secondary bacterial infections were identified. The risk factors of bacterial infection were evaluated. The outcomes of patients regarding co-infection or secondary bacterial infection were analyzed.
Results: We identified 117 critically ill patients with laboratory-confirmed influenza pneumonitis admitted to the medical ICUs. Klebsiella pneumoniae (31.4%) and Staphylococcus aureus (22.8%) were the most identified bacteria in patients with bacterial co-infection. A high proportion of methicillin-resistant Staphylococcus aureus (17.1%) was noted. Liver cirrhosis and diabetes mellitus were the independent risk factors for bacterial co-infection. Acinetobacter baumannii (30.7%) and S. aureus (23.1%) were the most often identified bacteria in patients with secondary bacterial pneumonia. Patients with secondary bacterial infections had a longer duration of mechanical ventilation, and longer ICU and hospital stay.
Conclusions: High rates of drug-resistant bacterial co-infections and secondary bacterial infections were identified in patients with severe influenza pneumonitis requiring ICU care and were associated with more morbidity in these patients.
Keywords: Acute respiratory failure; Bacterial co-infection; Bacterial secondary infection; Influenza; Pneumonitis.
. 2022 Oct 6;72:154164.
doi: 10.1016/j.jcrc.2022.154164. Online ahead of print.
The impacts of bacterial co-infections and secondary bacterial infections on patients with severe influenza pneumonitis admitted to the intensive care units
Wei-Chun Lee[SUP] 1 [/SUP], Meng-Chin Ho[SUP] 1 [/SUP], Shaw-Woei Leu[SUP] 2 [/SUP], Che-Chia Chang[SUP] 1 [/SUP], Chin-Kuo Lin[SUP] 1 [/SUP], Chieh-Mo Lin[SUP] 1 [/SUP], Yu-Hung Fang[SUP] 1 [/SUP], Shu-Yi Huang[SUP] 1 [/SUP], Yu-Ching Lin[SUP] 3 [/SUP], Min-Chun Chuang[SUP] 1 [/SUP], Tsung-Ming Yang[SUP] 1 [/SUP], Ming-Szu Hung[SUP] 3 [/SUP], Yen-Li Chou[SUP] 1 [/SUP], Ying-Huang Tsai[SUP] 4 [/SUP], Meng-Jer Hsieh[SUP] 5 [/SUP]
Affiliations
- PMID: 36209697
- DOI: 10.1016/j.jcrc.2022.154164
Abstract
Purposes: This study investigated the prevalence and clinical outcomes of pulmonary bacterial co-infections and secondary bacterial infections in patients with severe influenza pneumonitis.
Methods: We retrospectively analyzed the data of adult patients with severe influenza pneumonitis admitted to medical ICUs. Bacterial co-infections and secondary bacterial infections were identified. The risk factors of bacterial infection were evaluated. The outcomes of patients regarding co-infection or secondary bacterial infection were analyzed.
Results: We identified 117 critically ill patients with laboratory-confirmed influenza pneumonitis admitted to the medical ICUs. Klebsiella pneumoniae (31.4%) and Staphylococcus aureus (22.8%) were the most identified bacteria in patients with bacterial co-infection. A high proportion of methicillin-resistant Staphylococcus aureus (17.1%) was noted. Liver cirrhosis and diabetes mellitus were the independent risk factors for bacterial co-infection. Acinetobacter baumannii (30.7%) and S. aureus (23.1%) were the most often identified bacteria in patients with secondary bacterial pneumonia. Patients with secondary bacterial infections had a longer duration of mechanical ventilation, and longer ICU and hospital stay.
Conclusions: High rates of drug-resistant bacterial co-infections and secondary bacterial infections were identified in patients with severe influenza pneumonitis requiring ICU care and were associated with more morbidity in these patients.
Keywords: Acute respiratory failure; Bacterial co-infection; Bacterial secondary infection; Influenza; Pneumonitis.