tetano
Editor, Senior Moderator
J Endocrinol Invest
. 2021 Jun 8.
doi: 10.1007/s40618-021-01599-0. Online ahead of print.
Thyroid dysfunction in COVID-19 patients
R Baldelli[SUP] 1 [/SUP], E Nicastri[SUP] 2 [/SUP], N Petrosillo[SUP] 2 [/SUP], L Marchioni[SUP] 2 [/SUP], A Gubbiotti[SUP] 3 [/SUP], I Sperduti[SUP] 4 [/SUP], P Di Giacinto[SUP] 1 [/SUP], L Rizza[SUP] 1 [/SUP], F Rota[SUP] 1 [/SUP], M Franco[SUP] 5 [/SUP], A Lania[SUP] 6 [/SUP], G Aimaretti[SUP] 7 [/SUP], G Ippolito[SUP] 2 [/SUP], P Zuppi[SUP] 1 [/SUP]
Affiliations
Abstract
Purpose: "Non thyroidal illness syndrome" (NTIS) or "euthyroid sick syndrome" (ESS) is a possible biochemical finding in euthyroid patients with severe diseases. It is characterized by a reduction of serum T[SUB]3[/SUB] (fT3), sometimes followed by reduction of serum T[SUB]4[/SUB] (fT4). The relationship between thyroid hormones levels and mortality is well known and different studies showed a direct association between NTIS and mortality. The sudden spread of the 2019 novel coronavirus (SARS-CoV 2) infection (COVID-19) and its high mortality become a world healthcare problem. Our aim in this paper was to investigate if patients affected by COVID-19 presented NTIS and the relationship between thyroid function and severity of this infection.
Methods: We evaluated the thyroid function in two different groups of consecutive patients affected by COVID-19 with respect to a control group of euthyroid patients. Group A included patients hospitalized for COVID-19 pneumonia while patients requiring intensive care unit (ICU) for acute respiratory syndrome formed the group B. Group C identified the control group of euthyroid patients.
Results: Patients from group A and group B showed a statistically significant reduction in fT3 and TSH compared to group C. In group B, compared to group A, a further statistically significant reduction of fT3 and TSH was found.
Conclusions: COVID-19 in-patients can present NTIS. FT3 and TSH serum levels are lower in patients with more severe symptoms.
Keywords: COVID-19; Euthyroid sick syndrome; Non-thyroidal illness syndrome; SARS-CoV 2; Thyroid function; Thyroid hormones.
. 2021 Jun 8.
doi: 10.1007/s40618-021-01599-0. Online ahead of print.
Thyroid dysfunction in COVID-19 patients
R Baldelli[SUP] 1 [/SUP], E Nicastri[SUP] 2 [/SUP], N Petrosillo[SUP] 2 [/SUP], L Marchioni[SUP] 2 [/SUP], A Gubbiotti[SUP] 3 [/SUP], I Sperduti[SUP] 4 [/SUP], P Di Giacinto[SUP] 1 [/SUP], L Rizza[SUP] 1 [/SUP], F Rota[SUP] 1 [/SUP], M Franco[SUP] 5 [/SUP], A Lania[SUP] 6 [/SUP], G Aimaretti[SUP] 7 [/SUP], G Ippolito[SUP] 2 [/SUP], P Zuppi[SUP] 1 [/SUP]
Affiliations
- PMID: 34101132
- DOI: 10.1007/s40618-021-01599-0
Abstract
Purpose: "Non thyroidal illness syndrome" (NTIS) or "euthyroid sick syndrome" (ESS) is a possible biochemical finding in euthyroid patients with severe diseases. It is characterized by a reduction of serum T[SUB]3[/SUB] (fT3), sometimes followed by reduction of serum T[SUB]4[/SUB] (fT4). The relationship between thyroid hormones levels and mortality is well known and different studies showed a direct association between NTIS and mortality. The sudden spread of the 2019 novel coronavirus (SARS-CoV 2) infection (COVID-19) and its high mortality become a world healthcare problem. Our aim in this paper was to investigate if patients affected by COVID-19 presented NTIS and the relationship between thyroid function and severity of this infection.
Methods: We evaluated the thyroid function in two different groups of consecutive patients affected by COVID-19 with respect to a control group of euthyroid patients. Group A included patients hospitalized for COVID-19 pneumonia while patients requiring intensive care unit (ICU) for acute respiratory syndrome formed the group B. Group C identified the control group of euthyroid patients.
Results: Patients from group A and group B showed a statistically significant reduction in fT3 and TSH compared to group C. In group B, compared to group A, a further statistically significant reduction of fT3 and TSH was found.
Conclusions: COVID-19 in-patients can present NTIS. FT3 and TSH serum levels are lower in patients with more severe symptoms.
Keywords: COVID-19; Euthyroid sick syndrome; Non-thyroidal illness syndrome; SARS-CoV 2; Thyroid function; Thyroid hormones.