tetano
Editor, Senior Moderator
J Gastrointestin Liver Dis
. 2020 Jun 3;29(2):219-226.
doi: 10.15403/jgld-.
Abnormal Liver Function Tests of Patients With Coronavirus Disease 2019 in Mainland China: A Systematic Review and Meta- Analysis
Shengliang Xin[SUP] 1 [/SUP], Jinghang Xu[SUP] 2 [/SUP], Yanyan Yu[SUP] 3 [/SUP]
Affiliations
Abstract
Aims: Comparing the risk of abnormal liver function tests between severe and non-severe patients with coronavirus disease 2019 (COVID-19) by meta-analysis.
Methods: A literature search was conducted using the databases PubMed, Embase, and Cochrane Library. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using fixed- or random-effects models. Publication bias was detected by the Harbord test.
Results: We included 8 articles comprising 7,467 COVID-19 patients. When compared between severe and non-severe COVID-19 patients, the pooled ORs of elevated alanine aminotransferase, aspartate aminotransferase, total bilirubin, and lactate dehydrogenase levels were 2.35 (95% CI 1.38-3.98), 3.21 (95% CI 2.59-3.98), 1.87 (95% CI 1.32-2.65), and 4.83 (95% CI 2.90-8.05), respectively.
Conclusions: The severity of COVID-19 is associated with liver damage, and can be a risk factor for abnormal liver function tests.
. 2020 Jun 3;29(2):219-226.
doi: 10.15403/jgld-.
Abnormal Liver Function Tests of Patients With Coronavirus Disease 2019 in Mainland China: A Systematic Review and Meta- Analysis
Shengliang Xin[SUP] 1 [/SUP], Jinghang Xu[SUP] 2 [/SUP], Yanyan Yu[SUP] 3 [/SUP]
Affiliations
- PMID: 32530989
- DOI: 10.15403/jgld-
Abstract
Aims: Comparing the risk of abnormal liver function tests between severe and non-severe patients with coronavirus disease 2019 (COVID-19) by meta-analysis.
Methods: A literature search was conducted using the databases PubMed, Embase, and Cochrane Library. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using fixed- or random-effects models. Publication bias was detected by the Harbord test.
Results: We included 8 articles comprising 7,467 COVID-19 patients. When compared between severe and non-severe COVID-19 patients, the pooled ORs of elevated alanine aminotransferase, aspartate aminotransferase, total bilirubin, and lactate dehydrogenase levels were 2.35 (95% CI 1.38-3.98), 3.21 (95% CI 2.59-3.98), 1.87 (95% CI 1.32-2.65), and 4.83 (95% CI 2.90-8.05), respectively.
Conclusions: The severity of COVID-19 is associated with liver damage, and can be a risk factor for abnormal liver function tests.