tetano
Editor, Senior Moderator
J Infect Dis
. 2021 Dec 15;jiab604.
doi: 10.1093/infdis/jiab604. Online ahead of print.
High SARS-CoV-2 viral load and low CCL5 expression levels in the upper respiratory tract are associated with COVID-19 severity
Felipe Pérez-García[SUP] 1 2 3 [/SUP], María Martin-Vicente[SUP] 1 4 [/SUP], Rosa Lía Rojas-García[SUP] 1 [/SUP], Lucia Castilla-García[SUP] 5 [/SUP], María José Muñoz-Gomez[SUP] 1 [/SUP], Irene Hervás Fernández[SUP] 2 [/SUP], Victoria González Ventosa[SUP] 2 [/SUP], Erick Joan Vidal-Alcántara[SUP] 1 [/SUP], Juan Cuadros-González[SUP] 2 3 [/SUP], Jesús F Bermejo-Martin[SUP] 6 7 8 [/SUP], Salvador Resino[SUP] 1 4 [/SUP], Isidoro Martínez[SUP] 1 4 [/SUP]
Affiliations
Abstract
Mucosal immune response in the upper respiratory tract is crucial for the initial control of viral replication, the clearance of SARS-CoV-2, and the progression of the coronavirus disease 2019 (COVID-19). We analyzed the SARS-CoV-2 RNA load and the expression of selected immune genes in the upper respiratory tract (nasopharynx) of 255 SARS-CoV-2 infected patients and evaluated their association with severe COVID-19. SARS-CoV-2 replication in the nasopharyngeal mucosa induces the expression of several innate immune genes. High SARS-CoV-2 viral load and low CCL5 expression levels were associated with ICU admission or death, although CCL5 was the best predictor of COVID-19 severity.
Keywords: CCL5; COVID-19; ICU; SARS-CoV-2; death; gene expression; innate immunity; nasopharynx; viral load.
. 2021 Dec 15;jiab604.
doi: 10.1093/infdis/jiab604. Online ahead of print.
High SARS-CoV-2 viral load and low CCL5 expression levels in the upper respiratory tract are associated with COVID-19 severity
Felipe Pérez-García[SUP] 1 2 3 [/SUP], María Martin-Vicente[SUP] 1 4 [/SUP], Rosa Lía Rojas-García[SUP] 1 [/SUP], Lucia Castilla-García[SUP] 5 [/SUP], María José Muñoz-Gomez[SUP] 1 [/SUP], Irene Hervás Fernández[SUP] 2 [/SUP], Victoria González Ventosa[SUP] 2 [/SUP], Erick Joan Vidal-Alcántara[SUP] 1 [/SUP], Juan Cuadros-González[SUP] 2 3 [/SUP], Jesús F Bermejo-Martin[SUP] 6 7 8 [/SUP], Salvador Resino[SUP] 1 4 [/SUP], Isidoro Martínez[SUP] 1 4 [/SUP]
Affiliations
- PMID: 34910814
- DOI: 10.1093/infdis/jiab604
Abstract
Mucosal immune response in the upper respiratory tract is crucial for the initial control of viral replication, the clearance of SARS-CoV-2, and the progression of the coronavirus disease 2019 (COVID-19). We analyzed the SARS-CoV-2 RNA load and the expression of selected immune genes in the upper respiratory tract (nasopharynx) of 255 SARS-CoV-2 infected patients and evaluated their association with severe COVID-19. SARS-CoV-2 replication in the nasopharyngeal mucosa induces the expression of several innate immune genes. High SARS-CoV-2 viral load and low CCL5 expression levels were associated with ICU admission or death, although CCL5 was the best predictor of COVID-19 severity.
Keywords: CCL5; COVID-19; ICU; SARS-CoV-2; death; gene expression; innate immunity; nasopharynx; viral load.