tetano
Editor, Senior Moderator
J Infect Dis
. 2024 Jul 25;230(1):28-37.
doi: 10.1093/infdis/jiae061. Regulatory T and CXCR3+ Circulating Tfh Cells Concordantly Shape the Neutralizing Antibody Responses in Individuals Who Have Recovered from Mild COVID-19
Xingyu Zheng[SUP] 1 2 [/SUP], Rui Lu[SUP] 1 2 [/SUP], Dong Pan[SUP] 1 2 [/SUP], Liting Peng[SUP] 1 2 [/SUP], Rongzhang He[SUP] 2 [/SUP], Yabin Hu[SUP] 2 [/SUP], Jun Chen[SUP] 2 [/SUP], Jinyong Tang[SUP] 2 [/SUP], Xiaohan Rong[SUP] 2 [/SUP], Shishan Teng[SUP] 2 [/SUP], You Wang[SUP] 2 3 [/SUP], Fen Liu[SUP] 1 2 [/SUP], Tianyi Xie[SUP] 1 2 [/SUP], Chanfeng Wu[SUP] 1 2 [/SUP], Yinggen Tang[SUP] 2 3 [/SUP], Wenpei Liu[SUP] 1 [/SUP], Xiaowang Qu[SUP] 1 [/SUP]
Affiliations
Regulatory T (Treg) cells are involved in the antiviral immune response in patients with coronavirus disease 2019 (COVID-19); however, whether Treg cells are involved in the neutralizing antibody (nAb) response remains unclear. Here, we found that individuals who recovered from mild but not severe COVID-19 had significantly greater frequencies of Treg cells and lower frequencies of CXCR3+ circulating T follicular helper (cTfh) cells than healthy controls. Furthermore, the frequencies of Treg and CXCR3+ cTfh cells were negatively and positively correlated with the nAb responses, respectively, and Treg cells was inversely associated with CXCR3+ cTfh cells in individuals who recovered from mild COVID-19 but not in those with severe disease. Mechanistically, Treg cells inhibited memory B-cell differentiation and antibody production by limiting the activation and proliferation of cTfh cells, especially CXCR3+ cTfh cells, and functional molecule expression. This study provides novel insight showing that mild COVID-19 elicits concerted nAb responses, which are shaped by both Treg and Tfh cells.
Keywords: COVID-19; circulating T-follicular helper cell; neutralizing antibody; regulatory T cell.
. 2024 Jul 25;230(1):28-37.
doi: 10.1093/infdis/jiae061. Regulatory T and CXCR3+ Circulating Tfh Cells Concordantly Shape the Neutralizing Antibody Responses in Individuals Who Have Recovered from Mild COVID-19
Xingyu Zheng[SUP] 1 2 [/SUP], Rui Lu[SUP] 1 2 [/SUP], Dong Pan[SUP] 1 2 [/SUP], Liting Peng[SUP] 1 2 [/SUP], Rongzhang He[SUP] 2 [/SUP], Yabin Hu[SUP] 2 [/SUP], Jun Chen[SUP] 2 [/SUP], Jinyong Tang[SUP] 2 [/SUP], Xiaohan Rong[SUP] 2 [/SUP], Shishan Teng[SUP] 2 [/SUP], You Wang[SUP] 2 3 [/SUP], Fen Liu[SUP] 1 2 [/SUP], Tianyi Xie[SUP] 1 2 [/SUP], Chanfeng Wu[SUP] 1 2 [/SUP], Yinggen Tang[SUP] 2 3 [/SUP], Wenpei Liu[SUP] 1 [/SUP], Xiaowang Qu[SUP] 1 [/SUP]
Affiliations
- PMID: 39052730
- DOI: 10.1093/infdis/jiae061
Regulatory T (Treg) cells are involved in the antiviral immune response in patients with coronavirus disease 2019 (COVID-19); however, whether Treg cells are involved in the neutralizing antibody (nAb) response remains unclear. Here, we found that individuals who recovered from mild but not severe COVID-19 had significantly greater frequencies of Treg cells and lower frequencies of CXCR3+ circulating T follicular helper (cTfh) cells than healthy controls. Furthermore, the frequencies of Treg and CXCR3+ cTfh cells were negatively and positively correlated with the nAb responses, respectively, and Treg cells was inversely associated with CXCR3+ cTfh cells in individuals who recovered from mild COVID-19 but not in those with severe disease. Mechanistically, Treg cells inhibited memory B-cell differentiation and antibody production by limiting the activation and proliferation of cTfh cells, especially CXCR3+ cTfh cells, and functional molecule expression. This study provides novel insight showing that mild COVID-19 elicits concerted nAb responses, which are shaped by both Treg and Tfh cells.
Keywords: COVID-19; circulating T-follicular helper cell; neutralizing antibody; regulatory T cell.