tetano
Editor, Senior Moderator
J Intern Med
. 2021 Mar 2.
doi: 10.1111/joim.13275. Online ahead of print.
Arterial stiffness in acute COVID-19 and potential associations with clinical outcome
Sebastian Schnaubelt[SUP] 1 [/SUP], Julia Oppenauer[SUP] 1 [/SUP], Daniel Tihanyi[SUP] 2 [/SUP], Markus Mueller[SUP] 3 [/SUP], Eduardo Maldonado-Gonzalez[SUP] 4 [/SUP], Sara Zejnilovic[SUP] 1 [/SUP], Helmuth Haslacher[SUP] 5 [/SUP], Thomas Perkmann[SUP] 5 [/SUP], Robert Strassl[SUP] 6 [/SUP], Sonja Anders[SUP] 2 [/SUP], Thomas Stefenelli[SUP] 4 [/SUP], Sonja Zehetmayer[SUP] 7 [/SUP], Renate Koppensteiner[SUP] 3 [/SUP], Hans Domanovits[SUP] 1 [/SUP], Oliver Schlager[SUP] 3 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) interferes with the vascular endothelium. It is not known whether COVID-19 additionally affects arterial stiffness.
Methods: This case-control study compared brachial-ankle pulse wave (baPWV)- and carotid-femoral pulse wave velocities (cfPWV) of acutely-ill patients with- and without COVID-19.
Results: Twenty-two COVID-19 patients (50% females, 77 [67-84] years) were compared with 22 age- and sex-matched controls. In COVID-19 patients, baPWV (19.9 [18.4-21.0] vs. 16.0 [14.2-20.4], p=0.02) and cfPWV (14.3 [13.4-16.0] vs. 11.0 [9.5-14.6], p=0.01) were higher than in the controls. In multiple regression analysis, COVID-19 was independently associated with higher cfPWV (β=3.164, p=0.004) and baPWV (β=3.532, p=0.003). PWV values were higher in non-survivors. In survivors, PWV correlated with length of hospital stay.
Conclusion: COVID-19 appears to be related to an enhanced PWV reflecting an increase in arterial stiffness. Higher PWV might be related to an increased length of hospital stay and mortality.
Keywords: COVID-19; SARS-CoV-2; arterial stiffness; cardiovascular risk; pulse wave velocity.
. 2021 Mar 2.
doi: 10.1111/joim.13275. Online ahead of print.
Arterial stiffness in acute COVID-19 and potential associations with clinical outcome
Sebastian Schnaubelt[SUP] 1 [/SUP], Julia Oppenauer[SUP] 1 [/SUP], Daniel Tihanyi[SUP] 2 [/SUP], Markus Mueller[SUP] 3 [/SUP], Eduardo Maldonado-Gonzalez[SUP] 4 [/SUP], Sara Zejnilovic[SUP] 1 [/SUP], Helmuth Haslacher[SUP] 5 [/SUP], Thomas Perkmann[SUP] 5 [/SUP], Robert Strassl[SUP] 6 [/SUP], Sonja Anders[SUP] 2 [/SUP], Thomas Stefenelli[SUP] 4 [/SUP], Sonja Zehetmayer[SUP] 7 [/SUP], Renate Koppensteiner[SUP] 3 [/SUP], Hans Domanovits[SUP] 1 [/SUP], Oliver Schlager[SUP] 3 [/SUP]
Affiliations
- PMID: 33651387
- DOI: 10.1111/joim.13275
Abstract
Background: Coronavirus disease 2019 (COVID-19) interferes with the vascular endothelium. It is not known whether COVID-19 additionally affects arterial stiffness.
Methods: This case-control study compared brachial-ankle pulse wave (baPWV)- and carotid-femoral pulse wave velocities (cfPWV) of acutely-ill patients with- and without COVID-19.
Results: Twenty-two COVID-19 patients (50% females, 77 [67-84] years) were compared with 22 age- and sex-matched controls. In COVID-19 patients, baPWV (19.9 [18.4-21.0] vs. 16.0 [14.2-20.4], p=0.02) and cfPWV (14.3 [13.4-16.0] vs. 11.0 [9.5-14.6], p=0.01) were higher than in the controls. In multiple regression analysis, COVID-19 was independently associated with higher cfPWV (β=3.164, p=0.004) and baPWV (β=3.532, p=0.003). PWV values were higher in non-survivors. In survivors, PWV correlated with length of hospital stay.
Conclusion: COVID-19 appears to be related to an enhanced PWV reflecting an increase in arterial stiffness. Higher PWV might be related to an increased length of hospital stay and mortality.
Keywords: COVID-19; SARS-CoV-2; arterial stiffness; cardiovascular risk; pulse wave velocity.