tetano
Editor, Senior Moderator
J King Saud Univ Sci
. 2021 Jan;33(1):101255.
doi: 10.1016/j.jksus.2020.101255. Epub 2020 Dec 2.
Evaluating antibody response pattern in asymptomatic virus infected pregnant females: Human well-being study
Ashaq Ali[SUP] 1 2 [/SUP], Zubia Rashid[SUP] 3 [/SUP], Jieqiong Zhou[SUP] 4 5 [/SUP], Muhammad Zubair Yousaf[SUP] 6 [/SUP], Saddia Galani[SUP] 7 [/SUP], Asma Ashraf[SUP] 8 [/SUP], Khalid A Al-Ghanim[SUP] 9 [/SUP], Emin Al-Suliman[SUP] 9 [/SUP], Zubair Ahmed[SUP] 9 [/SUP], Muhammad Farooq[SUP] 9 [/SUP], Promy Virik[SUP] 9 [/SUP], Z A Kaimkhani[SUP] 10 [/SUP], Norah Al-Mulhm[SUP] 9 [/SUP], Shahid Mahboob[SUP] 9 [/SUP], Men Dong[SUP] 1 2 [/SUP], Qiuxiang Huang[SUP] 5 [/SUP]
Affiliations
Abstract
The ongoing SARS-CoV-2 pandemic infecting millions of people globally has given rise to serious public health threats. The need for early detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic pregnant women is compelling to detect vertical transmission timely. Here, 11 SARS-CoV-2 asymptomatic pregnant cases from Wuhan China were investigated. All the patients were initially tested negative for SARS-CoV-2 on RT-PCR, so a chest CT scan was performed. Also, serum antibody (IgM and IgG) titers were estimated. CT scan of patients revealed typical abnormalities related to SARS-CoV-2, indicating ground-glass opacity and infection lesions suggesting viral pneumonia. Elevated IgM and IgG antibodies levels (p < 0.001) were also noticed in infected patients. Hence, CT imaging and serum antibody response are valuable in the early detection of SARS-CoV-2 in asymptomatic pregnant patients. These might serve as prognostic markers for healthcare professionals, in RT-PCR negative patients, to assess the effect of given treatment by chest CT.
Keywords: Asymptomatic; CT scan; Pregnant women; SARS-CoV-2; Serum antibodies.
. 2021 Jan;33(1):101255.
doi: 10.1016/j.jksus.2020.101255. Epub 2020 Dec 2.
Evaluating antibody response pattern in asymptomatic virus infected pregnant females: Human well-being study
Ashaq Ali[SUP] 1 2 [/SUP], Zubia Rashid[SUP] 3 [/SUP], Jieqiong Zhou[SUP] 4 5 [/SUP], Muhammad Zubair Yousaf[SUP] 6 [/SUP], Saddia Galani[SUP] 7 [/SUP], Asma Ashraf[SUP] 8 [/SUP], Khalid A Al-Ghanim[SUP] 9 [/SUP], Emin Al-Suliman[SUP] 9 [/SUP], Zubair Ahmed[SUP] 9 [/SUP], Muhammad Farooq[SUP] 9 [/SUP], Promy Virik[SUP] 9 [/SUP], Z A Kaimkhani[SUP] 10 [/SUP], Norah Al-Mulhm[SUP] 9 [/SUP], Shahid Mahboob[SUP] 9 [/SUP], Men Dong[SUP] 1 2 [/SUP], Qiuxiang Huang[SUP] 5 [/SUP]
Affiliations
- PMID: 33288976
- PMCID: PMC7709611
- DOI: 10.1016/j.jksus.2020.101255
Abstract
The ongoing SARS-CoV-2 pandemic infecting millions of people globally has given rise to serious public health threats. The need for early detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic pregnant women is compelling to detect vertical transmission timely. Here, 11 SARS-CoV-2 asymptomatic pregnant cases from Wuhan China were investigated. All the patients were initially tested negative for SARS-CoV-2 on RT-PCR, so a chest CT scan was performed. Also, serum antibody (IgM and IgG) titers were estimated. CT scan of patients revealed typical abnormalities related to SARS-CoV-2, indicating ground-glass opacity and infection lesions suggesting viral pneumonia. Elevated IgM and IgG antibodies levels (p < 0.001) were also noticed in infected patients. Hence, CT imaging and serum antibody response are valuable in the early detection of SARS-CoV-2 in asymptomatic pregnant patients. These might serve as prognostic markers for healthcare professionals, in RT-PCR negative patients, to assess the effect of given treatment by chest CT.
Keywords: Asymptomatic; CT scan; Pregnant women; SARS-CoV-2; Serum antibodies.