tetano
Editor, Senior Moderator
J Med Virol
. 2023 Oct;95(10):e29196.
doi: 10.1002/jmv.29196. Clinical and pathological features of omicron variant of SARS-CoV-2-associated kidney injury
Zhiwen Qi[SUP] 1 [/SUP], Shuguang Yuan[SUP] 1 [/SUP], Jinying Wei[SUP] 1 [/SUP], Shiyu Xia[SUP] 1 [/SUP], Yao Huang[SUP] 1 [/SUP], Xiaojun Chen[SUP] 1 [/SUP], Yachun Han[SUP] 1 [/SUP], Zheng Li[SUP] 1 [/SUP], Yang Xiao[SUP] 2 [/SUP], Fenghua Peng[SUP] 3 [/SUP], Xiao Fu[SUP] 1 [/SUP], Lin Sun[SUP] 1 [/SUP], Hong Liu[SUP] 1 [/SUP], Xuejing Zhu[SUP] 1 [/SUP]
Affiliations
Kidney injury is common in patients with Coronavirus Disease-19 (COVID-19), which is related to poor prognosis. We aim to summarize the clinical features, athological types, and prognosis of COVID-19 associated kidney injury caused by the Omicron strain. In this study, 46 patients with Omicron-associated kidney injury were included, 38 of whom performed renal biopsy. Patients were divided into two groups: group A for patients with onset of kidney injury after SARS-CoV-2 infection; group B for patients with pre-existing kidney disease who experienced aggravation of renal insufficiency after SARS-CoV-2 infection. The clinical, pathological, and prognostic characteristics of the patients were observed. Acute kidney injury (AKI) (35%) was the most common clinical manifestation in group A. Patients in group B mainly presented with chronic kidney disease (CKD) (55%) and nephrotic syndrome (NS) (40%). The pathological type was mainly IgA nephropathy (IgAN) (39% in group A and 45% in group B). Among all of them, one case presenting with thrombotic microangiopathy had worse kidney function at biopsy time. Mean serum C3 levels were 1.2 ± 0.5 and 1.0 ± 0.2 g/L in group A and group B, respectively. In renal tissues, C3 deposits were observed in 71.1% of patients. 11.8% (n = 2) patients experienced deterioration of renal function after treatment, but no patients developed to end-stage renal disease. In our single-center study in China, the main clinical manifestations were AKI, CKD, and NS, while the main pathological type was IgAN. Compared with previous strains of SARS-CoV-2, patients with the Omicron infection had a favorable prognosis.
Keywords: COVID-19; SARS-CoV-2; kidney injury; renal pathology.
. 2023 Oct;95(10):e29196.
doi: 10.1002/jmv.29196. Clinical and pathological features of omicron variant of SARS-CoV-2-associated kidney injury
Zhiwen Qi[SUP] 1 [/SUP], Shuguang Yuan[SUP] 1 [/SUP], Jinying Wei[SUP] 1 [/SUP], Shiyu Xia[SUP] 1 [/SUP], Yao Huang[SUP] 1 [/SUP], Xiaojun Chen[SUP] 1 [/SUP], Yachun Han[SUP] 1 [/SUP], Zheng Li[SUP] 1 [/SUP], Yang Xiao[SUP] 2 [/SUP], Fenghua Peng[SUP] 3 [/SUP], Xiao Fu[SUP] 1 [/SUP], Lin Sun[SUP] 1 [/SUP], Hong Liu[SUP] 1 [/SUP], Xuejing Zhu[SUP] 1 [/SUP]
Affiliations
- PMID: 37881096
- DOI: 10.1002/jmv.29196
Kidney injury is common in patients with Coronavirus Disease-19 (COVID-19), which is related to poor prognosis. We aim to summarize the clinical features, athological types, and prognosis of COVID-19 associated kidney injury caused by the Omicron strain. In this study, 46 patients with Omicron-associated kidney injury were included, 38 of whom performed renal biopsy. Patients were divided into two groups: group A for patients with onset of kidney injury after SARS-CoV-2 infection; group B for patients with pre-existing kidney disease who experienced aggravation of renal insufficiency after SARS-CoV-2 infection. The clinical, pathological, and prognostic characteristics of the patients were observed. Acute kidney injury (AKI) (35%) was the most common clinical manifestation in group A. Patients in group B mainly presented with chronic kidney disease (CKD) (55%) and nephrotic syndrome (NS) (40%). The pathological type was mainly IgA nephropathy (IgAN) (39% in group A and 45% in group B). Among all of them, one case presenting with thrombotic microangiopathy had worse kidney function at biopsy time. Mean serum C3 levels were 1.2 ± 0.5 and 1.0 ± 0.2 g/L in group A and group B, respectively. In renal tissues, C3 deposits were observed in 71.1% of patients. 11.8% (n = 2) patients experienced deterioration of renal function after treatment, but no patients developed to end-stage renal disease. In our single-center study in China, the main clinical manifestations were AKI, CKD, and NS, while the main pathological type was IgAN. Compared with previous strains of SARS-CoV-2, patients with the Omicron infection had a favorable prognosis.
Keywords: COVID-19; SARS-CoV-2; kidney injury; renal pathology.