tetano
Editor, Senior Moderator
J Med Virol
. 2023 Sep;95(9):e29092.
doi: 10.1002/jmv.29092. Molecular epidemiology of SARS-CoV-2 variants in circulation in the state of Maranhão, Brazil
Luis Artur Ferreira de Sousa[SUP] 1 2 [/SUP], Lucas Salomão de Sousa Ferreira[SUP] 2 [/SUP], Luis Felipe Lima Lobato[SUP] 2 3 [/SUP], Hivylla Lorrana Dos Santos Ferreira[SUP] 2 [/SUP], Lucas Henrique Dos Santos Sousa[SUP] 2 [/SUP], Valdenice Ferreira Dos Santos[SUP] 4 [/SUP], Paulo Ricardo Silva Nunes[SUP] 2 [/SUP], Carlos Eduardo Campos Maramaldo[SUP] 2 [/SUP], Sebastião Silveira Neto[SUP] 2 [/SUP], Hellen Lobato Sampaio[SUP] 1 [/SUP], Fabiano Vieira da Silva[SUP] 2 3 [/SUP], Marcelo da Costa Brito[SUP] 2 [/SUP], Washington Kleber Rodrigues Lima[SUP] 4 5 [/SUP], Claudia Zeneida Gomes Parente Alves Lima[SUP] 5 [/SUP], Lidio Gonçalves Lima Neto[SUP] 1 2 [/SUP]
Affiliations
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a coronavirus belonging to the beta CoV genus, responsible for SARS in humans, which became known as COVID-19. The emergence of variants of this virus is related to the presence of cases of reinfection, reduced vaccine effectiveness and greater transmission of the virus. Objective: In this study, we evaluated the molecular epidemiology of SARS-CoV-2 lineages circulating in the state of Maranhão. This is a cross-sectional and retrospective epidemiological study of genomic surveillance of SARS-CoV-2. The study comprised of 338 genomes sequenced by the Next Generation Sequencing technique on Illumina's Miseq equipment, submitted to Global Initiative on Sharing Avian Influenza Data, 190 (56.2%) are from samples of female and 148 (43.8%) from male patients. Sequencing performed covered samples of patients aged between 1 and 108 years, with emphasis on the age groups from 30 to 39 years with 15.0% of sequenced genomes and 20 to 29 years with 12.4%. As for the distribution of sequenced genomes by health macro-regions, 285 (84.3%) are from cities in the northern macro-region. We evidenced the circulation of 29 lineages and sub-lineages, four of which belonging to the Delta variant (AY.43, AY.99.1, AY.99.2 and AY.101 responsible for 4.5% of the genomes) and the others belonging to the Omicron variant, with emphasis on: BA.1 and sub-lineages (42.8%); BA.4, BA.5 and sub-lineages (5.3% and 41.1%); the sub-lineages DL.1 and BQ.1 (5% and 2%). A strong genomic surveillance system allows the study of the natural history of the disease, when there is a resurgence of SARS-CoV-2 cases.
Keywords: SARS coronavirus; epidemiology; pandemics.
. 2023 Sep;95(9):e29092.
doi: 10.1002/jmv.29092. Molecular epidemiology of SARS-CoV-2 variants in circulation in the state of Maranhão, Brazil
Luis Artur Ferreira de Sousa[SUP] 1 2 [/SUP], Lucas Salomão de Sousa Ferreira[SUP] 2 [/SUP], Luis Felipe Lima Lobato[SUP] 2 3 [/SUP], Hivylla Lorrana Dos Santos Ferreira[SUP] 2 [/SUP], Lucas Henrique Dos Santos Sousa[SUP] 2 [/SUP], Valdenice Ferreira Dos Santos[SUP] 4 [/SUP], Paulo Ricardo Silva Nunes[SUP] 2 [/SUP], Carlos Eduardo Campos Maramaldo[SUP] 2 [/SUP], Sebastião Silveira Neto[SUP] 2 [/SUP], Hellen Lobato Sampaio[SUP] 1 [/SUP], Fabiano Vieira da Silva[SUP] 2 3 [/SUP], Marcelo da Costa Brito[SUP] 2 [/SUP], Washington Kleber Rodrigues Lima[SUP] 4 5 [/SUP], Claudia Zeneida Gomes Parente Alves Lima[SUP] 5 [/SUP], Lidio Gonçalves Lima Neto[SUP] 1 2 [/SUP]
Affiliations
- PMID: 37724346
- DOI: 10.1002/jmv.29092
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a coronavirus belonging to the beta CoV genus, responsible for SARS in humans, which became known as COVID-19. The emergence of variants of this virus is related to the presence of cases of reinfection, reduced vaccine effectiveness and greater transmission of the virus. Objective: In this study, we evaluated the molecular epidemiology of SARS-CoV-2 lineages circulating in the state of Maranhão. This is a cross-sectional and retrospective epidemiological study of genomic surveillance of SARS-CoV-2. The study comprised of 338 genomes sequenced by the Next Generation Sequencing technique on Illumina's Miseq equipment, submitted to Global Initiative on Sharing Avian Influenza Data, 190 (56.2%) are from samples of female and 148 (43.8%) from male patients. Sequencing performed covered samples of patients aged between 1 and 108 years, with emphasis on the age groups from 30 to 39 years with 15.0% of sequenced genomes and 20 to 29 years with 12.4%. As for the distribution of sequenced genomes by health macro-regions, 285 (84.3%) are from cities in the northern macro-region. We evidenced the circulation of 29 lineages and sub-lineages, four of which belonging to the Delta variant (AY.43, AY.99.1, AY.99.2 and AY.101 responsible for 4.5% of the genomes) and the others belonging to the Omicron variant, with emphasis on: BA.1 and sub-lineages (42.8%); BA.4, BA.5 and sub-lineages (5.3% and 41.1%); the sub-lineages DL.1 and BQ.1 (5% and 2%). A strong genomic surveillance system allows the study of the natural history of the disease, when there is a resurgence of SARS-CoV-2 cases.
Keywords: SARS coronavirus; epidemiology; pandemics.