tetano
Editor, Senior Moderator
J Med Virol
. 2022 Jul 14.
doi: 10.1002/jmv.28000. Online ahead of print.
The deciphering of the immune cells and marker signature in COVID-19 pathogenesis: An update
Saade Abdalkareem Jasim[SUP] 1 [/SUP], Roaa Salih Mahdi[SUP] 2 [/SUP], Dmitry Olegovich Bokov[SUP] 3 4 [/SUP], Mazin A A Najm[SUP] 5 [/SUP], Guzal N Sobirova[SUP] 6 [/SUP], Zarnigor O Bafoyeva[SUP] 6 [/SUP], Ahmed Taifi[SUP] 7 [/SUP], Ola Kamal A Alkadir[SUP] 8 [/SUP], Yasser Fakri Mustafa[SUP] 9 [/SUP], Rasoul Mirzaei[SUP] 10 [/SUP], Sajad Karampoor[SUP] 11 [/SUP]
Affiliations
Abstract
The precise interaction between the immune system and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to deciphering the pathogenesis of Coronavirus disease 2019 (COVID-19) and is also vital for developing novel therapeutic tools, including monoclonal antibodies, antivirals drugs, and vaccines. Viral infections need innate and adaptive immune reactions since the various immune components like neutrophils, macrophages, CD4[SUP]+[/SUP] T, CD8[SUP]+[/SUP] T, and B lymphocytes play different roles in various infections. Consequently, the characterization of innate and adaptive immune reactions toward SARS-CoV-2 is crucial to defining the pathogenicity of COVID-19. In this study, we explain what is currently understood concerning the conventional immune reactions to SARS-CoV-2 infection to shed light on the protective and pathogenic role of immune response in this case. Also, in particular, we investigate the in-depth roles of other immune mediators, including neutrophil elastase, serum amyloid A, and Syndecan, in the immunopathogenesis of COVID-19. This article is protected by copyright. All rights reserved.
Keywords: Adaptive immunity; COVID-19; Innate immunity; Neutrophil elastase; Pathogenesis
. 2022 Jul 14.
doi: 10.1002/jmv.28000. Online ahead of print.
The deciphering of the immune cells and marker signature in COVID-19 pathogenesis: An update
Saade Abdalkareem Jasim[SUP] 1 [/SUP], Roaa Salih Mahdi[SUP] 2 [/SUP], Dmitry Olegovich Bokov[SUP] 3 4 [/SUP], Mazin A A Najm[SUP] 5 [/SUP], Guzal N Sobirova[SUP] 6 [/SUP], Zarnigor O Bafoyeva[SUP] 6 [/SUP], Ahmed Taifi[SUP] 7 [/SUP], Ola Kamal A Alkadir[SUP] 8 [/SUP], Yasser Fakri Mustafa[SUP] 9 [/SUP], Rasoul Mirzaei[SUP] 10 [/SUP], Sajad Karampoor[SUP] 11 [/SUP]
Affiliations
- PMID: 35835586
- DOI: 10.1002/jmv.28000
Abstract
The precise interaction between the immune system and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to deciphering the pathogenesis of Coronavirus disease 2019 (COVID-19) and is also vital for developing novel therapeutic tools, including monoclonal antibodies, antivirals drugs, and vaccines. Viral infections need innate and adaptive immune reactions since the various immune components like neutrophils, macrophages, CD4[SUP]+[/SUP] T, CD8[SUP]+[/SUP] T, and B lymphocytes play different roles in various infections. Consequently, the characterization of innate and adaptive immune reactions toward SARS-CoV-2 is crucial to defining the pathogenicity of COVID-19. In this study, we explain what is currently understood concerning the conventional immune reactions to SARS-CoV-2 infection to shed light on the protective and pathogenic role of immune response in this case. Also, in particular, we investigate the in-depth roles of other immune mediators, including neutrophil elastase, serum amyloid A, and Syndecan, in the immunopathogenesis of COVID-19. This article is protected by copyright. All rights reserved.
Keywords: Adaptive immunity; COVID-19; Innate immunity; Neutrophil elastase; Pathogenesis