tetano
Editor, Senior Moderator
J Neurochem
. 2023 Oct 18.
doi: 10.1111/jnc.15985. Online ahead of print. COVID-19 and the impact on Alzheimer's disease pathology
Susana Furman[SUP] 1 [/SUP], Kim Green[SUP] 1 [/SUP], Thomas E Lane[SUP] 1 2 3 [/SUP]
Affiliations
Coronavirus disease 2019 (COVID-19) has rapidly escalated into a global pandemic that primarily affects older and immunocompromised individuals due to underlying clinical conditions and suppressed immune responses. Furthermore, COVID-19 patients exhibit a spectrum of neurological symptoms, indicating that COVID-19 can affect the brain in a variety of manners. Many studies, past and recent, suggest a connection between viral infections and an increased risk of neurodegeneration, raising concerns about the neurological effects of COVID-19 and the possibility that it may contribute to Alzheimer's disease (AD) onset or worsen already existing AD pathology through inflammatory processes given that both COVID-19 and AD share pathological features and risk factors. This leads us to question whether COVID-19 is a risk factor for AD and how these two conditions might influence each other. Considering the extensive reach of the COVID-19 pandemic and the devastating impact of the ongoing AD pandemic, their combined effects could have significant public health consequences worldwide.
Keywords: Alzheimer's disease; coronavirus; coronavirus disease 2019; neuropathology.
. 2023 Oct 18.
doi: 10.1111/jnc.15985. Online ahead of print. COVID-19 and the impact on Alzheimer's disease pathology
Susana Furman[SUP] 1 [/SUP], Kim Green[SUP] 1 [/SUP], Thomas E Lane[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 37850241
- DOI: 10.1111/jnc.15985
Coronavirus disease 2019 (COVID-19) has rapidly escalated into a global pandemic that primarily affects older and immunocompromised individuals due to underlying clinical conditions and suppressed immune responses. Furthermore, COVID-19 patients exhibit a spectrum of neurological symptoms, indicating that COVID-19 can affect the brain in a variety of manners. Many studies, past and recent, suggest a connection between viral infections and an increased risk of neurodegeneration, raising concerns about the neurological effects of COVID-19 and the possibility that it may contribute to Alzheimer's disease (AD) onset or worsen already existing AD pathology through inflammatory processes given that both COVID-19 and AD share pathological features and risk factors. This leads us to question whether COVID-19 is a risk factor for AD and how these two conditions might influence each other. Considering the extensive reach of the COVID-19 pandemic and the devastating impact of the ongoing AD pandemic, their combined effects could have significant public health consequences worldwide.
Keywords: Alzheimer's disease; coronavirus; coronavirus disease 2019; neuropathology.