tetano
Editor, Senior Moderator
J Virol
. 2025 Nov 4:e0156625.
doi: 10.1128/jvi.01566-25. Online ahead of print. Transmission of SARS-CoV-2 between ferrets in presence of pre-existing immunity
Chong Wang[SUP] #[/SUP][SUP] 1 2 [/SUP], Lei Shuai[SUP] #[/SUP][SUP] 1 2 [/SUP], Gongxun Zhong[SUP] #[/SUP][SUP] 1 2 [/SUP], Zhiyuan Wen[SUP] #[/SUP][SUP] 1 2 [/SUP], Renqiang Liu[SUP] 1 2 [/SUP], Qilong Liu[SUP] 1 [/SUP], Jinliang Wang[SUP] 1 2 [/SUP], Jinying Ge[SUP] 1 [/SUP], Xianfeng Zhang[SUP] 1 2 [/SUP], Yuntao Guan[SUP] 1 2 [/SUP], Xijun He[SUP] 1 2 [/SUP], Zhigao Bu[SUP] 1 2 3 [/SUP]
Affiliations
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), is characterized by its high contagiousness. The COVID-19 pandemic has exerted profound impacts on human society. The persistent circulation of SARS-CoV-2 in human populations continues to pose re-exposure risks for both vaccinated individuals and those with prior natural infection. Against this epidemiological background, there is an urgent need to characterize the transmission dynamics of SARS-CoV-2 in the context of pre-existing immunity. Using a ferret infection model, this study systematically addresses critical scientific questions, including viral transmission efficiency, temporal patterns of transmissibility, and the ability of pre-existing immunity to mitigate reinfection and viral shedding. The findings provide robust experimental evidence for elucidating the transmission mechanisms of SARS-CoV-2 and offer scientific insights to inform the rational design of optimized antiviral strategies.IMPORTANCEIn this study, a ferret infection model was used to systematically investigate SARS-CoV-2's in vivo transmission dynamics and modes with pre-existing immunity. By characterizing viral transmission efficiency, temporal shedding patterns, and immunity's role in mitigating re-infection severity and dissemination, it provides direct evidence for understanding SARS-CoV-2 spread in immune-exposed hosts. It quantifies how humoral immunity modulates viral load (primary/secondary infections) and ferret contact transmission. Findings establish a key SARS-CoV-2 transmission framework-pre-existing immunity shortens shedding, reduces secondary attack rates but retains residual transmissibility-fill knowledge gaps, guide vaccine/herd immunity/public health measures, and lay a foundation for predicting real-world transmission and antiviral policies via integrated endpoints.
Keywords: SARS-CoV-2; pre-existing immunity; transmission.
. 2025 Nov 4:e0156625.
doi: 10.1128/jvi.01566-25. Online ahead of print. Transmission of SARS-CoV-2 between ferrets in presence of pre-existing immunity
Chong Wang[SUP] #[/SUP][SUP] 1 2 [/SUP], Lei Shuai[SUP] #[/SUP][SUP] 1 2 [/SUP], Gongxun Zhong[SUP] #[/SUP][SUP] 1 2 [/SUP], Zhiyuan Wen[SUP] #[/SUP][SUP] 1 2 [/SUP], Renqiang Liu[SUP] 1 2 [/SUP], Qilong Liu[SUP] 1 [/SUP], Jinliang Wang[SUP] 1 2 [/SUP], Jinying Ge[SUP] 1 [/SUP], Xianfeng Zhang[SUP] 1 2 [/SUP], Yuntao Guan[SUP] 1 2 [/SUP], Xijun He[SUP] 1 2 [/SUP], Zhigao Bu[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 41186412
- DOI: 10.1128/jvi.01566-25
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), is characterized by its high contagiousness. The COVID-19 pandemic has exerted profound impacts on human society. The persistent circulation of SARS-CoV-2 in human populations continues to pose re-exposure risks for both vaccinated individuals and those with prior natural infection. Against this epidemiological background, there is an urgent need to characterize the transmission dynamics of SARS-CoV-2 in the context of pre-existing immunity. Using a ferret infection model, this study systematically addresses critical scientific questions, including viral transmission efficiency, temporal patterns of transmissibility, and the ability of pre-existing immunity to mitigate reinfection and viral shedding. The findings provide robust experimental evidence for elucidating the transmission mechanisms of SARS-CoV-2 and offer scientific insights to inform the rational design of optimized antiviral strategies.IMPORTANCEIn this study, a ferret infection model was used to systematically investigate SARS-CoV-2's in vivo transmission dynamics and modes with pre-existing immunity. By characterizing viral transmission efficiency, temporal shedding patterns, and immunity's role in mitigating re-infection severity and dissemination, it provides direct evidence for understanding SARS-CoV-2 spread in immune-exposed hosts. It quantifies how humoral immunity modulates viral load (primary/secondary infections) and ferret contact transmission. Findings establish a key SARS-CoV-2 transmission framework-pre-existing immunity shortens shedding, reduces secondary attack rates but retains residual transmissibility-fill knowledge gaps, guide vaccine/herd immunity/public health measures, and lay a foundation for predicting real-world transmission and antiviral policies via integrated endpoints.
Keywords: SARS-CoV-2; pre-existing immunity; transmission.