tetano
Editor, Senior Moderator
Leg Med (Tokyo)
. 2022 May 31;58:102098.
doi: 10.1016/j.legalmed.2022.102098. Online ahead of print.
A sudden death due to acute necrotizing encephalopathy associated with influenza A virus infection: An autopsy case report
Huang Weisheng[SUP] 1 [/SUP], Zhang Hui[SUP] 2 [/SUP], Wu Shuang[SUP] 3 [/SUP], Gao Qing[SUP] 1 [/SUP], Sun Tianying[SUP] 1 [/SUP], Yang Chenguang[SUP] 1 [/SUP], Dong Hongmei[SUP] 4 [/SUP]
Affiliations
Abstract
Influenza occasionally causes central nervous system disorders. Acute necrotizing encephalopathy (ANE) is one of the most severe influenza-associated complications, predominantly affecting infants and young children under 5 years of age. We present this case as it involves a very rare complication of influenza infection that is known to have a high rate of mortality. A 5-year-old girl presented with a high fever and convulsions. Her condition deteriorated rapidly, and she died within 24 h. Autopsy revealed extensive brain edema, multifocal perivascular hemorrhage, and necrosis of neurons without inflammatory cell infiltration in the pons and bilateral thalamus. Tests for influenza virus A and antibodies to it were positive. The girl's death was attributed to ANE associated with influenza A infection based on the clinical presentation, the postmortem neuropathology, and identification of the virus. The goal of this report is to draw attention to the potentially serious complications of influenza A infection. We hope that the lethal outcome of this disease will be fully recognized by medical personnel.
Keywords: Acute necrotizing encephalopathy; Autopsy; Influenza A; Pathology.
. 2022 May 31;58:102098.
doi: 10.1016/j.legalmed.2022.102098. Online ahead of print.
A sudden death due to acute necrotizing encephalopathy associated with influenza A virus infection: An autopsy case report
Huang Weisheng[SUP] 1 [/SUP], Zhang Hui[SUP] 2 [/SUP], Wu Shuang[SUP] 3 [/SUP], Gao Qing[SUP] 1 [/SUP], Sun Tianying[SUP] 1 [/SUP], Yang Chenguang[SUP] 1 [/SUP], Dong Hongmei[SUP] 4 [/SUP]
Affiliations
- PMID: 35662069
- DOI: 10.1016/j.legalmed.2022.102098
Abstract
Influenza occasionally causes central nervous system disorders. Acute necrotizing encephalopathy (ANE) is one of the most severe influenza-associated complications, predominantly affecting infants and young children under 5 years of age. We present this case as it involves a very rare complication of influenza infection that is known to have a high rate of mortality. A 5-year-old girl presented with a high fever and convulsions. Her condition deteriorated rapidly, and she died within 24 h. Autopsy revealed extensive brain edema, multifocal perivascular hemorrhage, and necrosis of neurons without inflammatory cell infiltration in the pons and bilateral thalamus. Tests for influenza virus A and antibodies to it were positive. The girl's death was attributed to ANE associated with influenza A infection based on the clinical presentation, the postmortem neuropathology, and identification of the virus. The goal of this report is to draw attention to the potentially serious complications of influenza A infection. We hope that the lethal outcome of this disease will be fully recognized by medical personnel.
Keywords: Acute necrotizing encephalopathy; Autopsy; Influenza A; Pathology.