tetano
Editor, Senior Moderator
Hum Vaccin Immunother. 2017 Dec 18:0. doi: 10.1080/21645515.2017.1417713. [Epub ahead of print]
[h=1]Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections.[/h] Korenkov D[SUP]1,[/SUP][SUP]2[/SUP], Nguyen T[SUP]2[/SUP], Isakova-Sivak I[SUP]1[/SUP], Smolonogina T[SUP]1[/SUP], Brown LE[SUP]2[/SUP], Kedzierska K[SUP]2[/SUP], Rudenko L[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Live attenuated influenza vaccines (LAIV) induce CD8[SUP]+[/SUP] T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal proteins of Russian LAIVs are derived from the master donor virus A/Leningrad/134/17/57 (Len/17) isolated 60 years ago and as such, some CD8[SUP]+[/SUP] T cell epitopes may vary between the vaccine and circulating wild-type strains. To partially overcome this issue, the nucleoprotein (NP) gene of wild-type virus can be incorporated into LAIV reassortant virus, along with the HA and NA genes. The present study compares the human CD8+ T cell memory responses to H3N2 LAIVs with the Len/17 or the wild-type NP using an in vitro model.
[h=4]KEYWORDS:[/h] Antigenic escape; Influenza; LAIV; T cell epitope; nucleoprotein
PMID: 29252117 DOI: 10.1080/21645515.2017.1417713
[h=1]Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections.[/h] Korenkov D[SUP]1,[/SUP][SUP]2[/SUP], Nguyen T[SUP]2[/SUP], Isakova-Sivak I[SUP]1[/SUP], Smolonogina T[SUP]1[/SUP], Brown LE[SUP]2[/SUP], Kedzierska K[SUP]2[/SUP], Rudenko L[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Live attenuated influenza vaccines (LAIV) induce CD8[SUP]+[/SUP] T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal proteins of Russian LAIVs are derived from the master donor virus A/Leningrad/134/17/57 (Len/17) isolated 60 years ago and as such, some CD8[SUP]+[/SUP] T cell epitopes may vary between the vaccine and circulating wild-type strains. To partially overcome this issue, the nucleoprotein (NP) gene of wild-type virus can be incorporated into LAIV reassortant virus, along with the HA and NA genes. The present study compares the human CD8+ T cell memory responses to H3N2 LAIVs with the Len/17 or the wild-type NP using an in vitro model.
[h=4]KEYWORDS:[/h] Antigenic escape; Influenza; LAIV; T cell epitope; nucleoprotein
PMID: 29252117 DOI: 10.1080/21645515.2017.1417713