tetano
Editor, Senior Moderator
Acta Haematol. 2011 Mar 11;126(1):1-7. [Epub ahead of print]
Management of the 2009 A/H1N1 Influenza Pandemic in Patients with Hematologic Diseases: A Prospective Experience at an Italian Center.
Girmenia C, Mercanti C, Federico V, Rea M, De Vellis A, Valle V, Micozzi A, Latagliata R, Breccia M, Morano SG, Brunetti GA, Sali M, Delogu G, Fo? R, Alimena G, Gentile G.
Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerative, Azienda Policlinico Umberto I, Sapienza Universit? di Roma, Roma, Italia.
Abstract
Data derived from epidemiologic surveillance adopted at our center in hematologic and stem cell transplant patients during the 2009 influenza A (H1N1)v pandemic are reported. Of the 52 patients with influenza-like disease we observed, 37 underwent a real-time PCR evaluation and 21 had a confirmed diagnosis. Of the RT-PCR-confirmed cases, 23.8% were children (age <18 years) and 9.5% were >65 years; 47.6% presented with a pulmonary infiltrate and 33.3% with respiratory failure. Pulmonary involvement was observed more frequently in patients with comorbidities. All patients received a course of oseltamivir therapy starting an average of 1 day (range <1-2) after the onset of symptoms. No patient was transferred to the intensive care unit. The viral disease had a generally favorable outcome despite the high frequency of pulmonary involvement. A prompt clinical evaluation with an early antiviral and supportive therapy may have played a beneficial role in the outcome.
Copyright ? 2011 S. Karger AG, Basel.
PMID: 21411983 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21411983
Management of the 2009 A/H1N1 Influenza Pandemic in Patients with Hematologic Diseases: A Prospective Experience at an Italian Center.
Girmenia C, Mercanti C, Federico V, Rea M, De Vellis A, Valle V, Micozzi A, Latagliata R, Breccia M, Morano SG, Brunetti GA, Sali M, Delogu G, Fo? R, Alimena G, Gentile G.
Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerative, Azienda Policlinico Umberto I, Sapienza Universit? di Roma, Roma, Italia.
Abstract
Data derived from epidemiologic surveillance adopted at our center in hematologic and stem cell transplant patients during the 2009 influenza A (H1N1)v pandemic are reported. Of the 52 patients with influenza-like disease we observed, 37 underwent a real-time PCR evaluation and 21 had a confirmed diagnosis. Of the RT-PCR-confirmed cases, 23.8% were children (age <18 years) and 9.5% were >65 years; 47.6% presented with a pulmonary infiltrate and 33.3% with respiratory failure. Pulmonary involvement was observed more frequently in patients with comorbidities. All patients received a course of oseltamivir therapy starting an average of 1 day (range <1-2) after the onset of symptoms. No patient was transferred to the intensive care unit. The viral disease had a generally favorable outcome despite the high frequency of pulmonary involvement. A prompt clinical evaluation with an early antiviral and supportive therapy may have played a beneficial role in the outcome.
Copyright ? 2011 S. Karger AG, Basel.
PMID: 21411983 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21411983