Giuseppe
Emeritus
A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm (mBio, abstract, edited)
[Source: mBio, full page: <cite cite="http://mbio.asm.org/content/2/1/e00325-10.short?rss=1">A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm ? mBio</cite>. Abstract, edited.]
A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm
1. Alan Aderem a, 2. Joshua N. Adkins b, 3. Charles Ansong b, 4. James Galagan c,d,e, 5. Shari Kaiser a, 6. Marcus J. Korth f, 7. G. Lynn Law f, 8. Jason G. McDermott b, 9. Sean C. Proll f, 10. Carrie Rosenberger a, 11. Gary Schoolnik g, and 12. Michael G. Katze f,h
Author Affiliations
1. Institute for Systems Biology, Seattle, Washington, USA(a);
2. Fundamental and Computational Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA(b);
3. Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA(c);
4. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA(d);
5. National Emerging Infectious Diseases Laboratory, Boston University, Boston, Massachusetts, USA(e);
6. Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA(f);
7. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA(g); and
8. Washington National Primate Research Center, University of Washington, Seattle, Washington, USA(h)
1. Address correspondence to M. G. Katze at honey@uw.edu.
ABSTRACT
The twentieth century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and waterborne illnesses are frequent, multidrug-resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the past?including the intense focus on individual genes and proteins typical of molecular biology?have not been sufficient to address these challenges. The first decade of the twenty-first century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program, we think that the time is at hand to redefine the pathogen-host research paradigm.
Footnotes
* Citation Aderem, A., J. N. Adkins, C. Ansong, J. Galagan, S. Kaiser, et al. 2011. A systems biology approach to infectious disease research: innovating the pathogen-host research paradigm. mBio 2(1):e00325-10. doi:10.1128/mBio.00325-10.
* Copyright ? 2011 Aderem et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
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[Source: mBio, full page: <cite cite="http://mbio.asm.org/content/2/1/e00325-10.short?rss=1">A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm ? mBio</cite>. Abstract, edited.]
A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm
1. Alan Aderem a, 2. Joshua N. Adkins b, 3. Charles Ansong b, 4. James Galagan c,d,e, 5. Shari Kaiser a, 6. Marcus J. Korth f, 7. G. Lynn Law f, 8. Jason G. McDermott b, 9. Sean C. Proll f, 10. Carrie Rosenberger a, 11. Gary Schoolnik g, and 12. Michael G. Katze f,h
Author Affiliations
1. Institute for Systems Biology, Seattle, Washington, USA(a);
2. Fundamental and Computational Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA(b);
3. Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA(c);
4. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA(d);
5. National Emerging Infectious Diseases Laboratory, Boston University, Boston, Massachusetts, USA(e);
6. Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, USA(f);
7. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA(g); and
8. Washington National Primate Research Center, University of Washington, Seattle, Washington, USA(h)
1. Address correspondence to M. G. Katze at honey@uw.edu.
ABSTRACT
The twentieth century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and waterborne illnesses are frequent, multidrug-resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the past?including the intense focus on individual genes and proteins typical of molecular biology?have not been sufficient to address these challenges. The first decade of the twenty-first century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program, we think that the time is at hand to redefine the pathogen-host research paradigm.
Footnotes
* Citation Aderem, A., J. N. Adkins, C. Ansong, J. Galagan, S. Kaiser, et al. 2011. A systems biology approach to infectious disease research: innovating the pathogen-host research paradigm. mBio 2(1):e00325-10. doi:10.1128/mBio.00325-10.
* Copyright ? 2011 Aderem et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
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