tetano
Editor, Senior Moderator
mBio
. 2023 Dec 19:e0225023.
doi: 10.1128/mbio.02250-23. Online ahead of print. The post-COVID-19 population has a high prevalence of cross-reactive antibodies to spikes from all Orthocoronavirinae genera
Gagandeep Singh[SUP] 1 2 [/SUP], Anass Abbad[SUP] 1 2 [/SUP], Giulio Kleiner[SUP] 1 2 [/SUP], Komal Srivastava[SUP] 1 2 [/SUP], Charles Gleason[SUP] 1 2 [/SUP]; PARIS Study Group[SUP] 1 2 [/SUP]; Juan Manuel Carreño[SUP] 1 2 [/SUP], Viviana Simon[SUP] 1 2 3 4 5 [/SUP], Florian Krammer[SUP] 1 2 3 [/SUP]
Collaborators, Affiliations
As demonstrated by severe acute respiratory syndrome coronavirus 2, coronaviruses pose a significant pandemic threat. Here, we show that coronavirus disease 2019 mRNA vaccination can induce significant levels of cross-reactive antibodies against diverse coronavirus spike proteins. While these antibodies are binding antibodies that likely have little neutralization capacity and while their contribution to cross-protection is unclear, it is possible that they may play a role in protection from progression to severe disease with novel coronaviruses.
Keywords: Orthocoronavirinae; SARS-CoV-2 immunity; antibodies; cross-reactivity.
. 2023 Dec 19:e0225023.
doi: 10.1128/mbio.02250-23. Online ahead of print. The post-COVID-19 population has a high prevalence of cross-reactive antibodies to spikes from all Orthocoronavirinae genera
Gagandeep Singh[SUP] 1 2 [/SUP], Anass Abbad[SUP] 1 2 [/SUP], Giulio Kleiner[SUP] 1 2 [/SUP], Komal Srivastava[SUP] 1 2 [/SUP], Charles Gleason[SUP] 1 2 [/SUP]; PARIS Study Group[SUP] 1 2 [/SUP]; Juan Manuel Carreño[SUP] 1 2 [/SUP], Viviana Simon[SUP] 1 2 3 4 5 [/SUP], Florian Krammer[SUP] 1 2 3 [/SUP]
Collaborators, Affiliations
- PMID: 38112467
- DOI: 10.1128/mbio.02250-23
As demonstrated by severe acute respiratory syndrome coronavirus 2, coronaviruses pose a significant pandemic threat. Here, we show that coronavirus disease 2019 mRNA vaccination can induce significant levels of cross-reactive antibodies against diverse coronavirus spike proteins. While these antibodies are binding antibodies that likely have little neutralization capacity and while their contribution to cross-protection is unclear, it is possible that they may play a role in protection from progression to severe disease with novel coronaviruses.
Keywords: Orthocoronavirinae; SARS-CoV-2 immunity; antibodies; cross-reactivity.