tetano
Editor, Senior Moderator
J Infect Dis. 2017 May 11. doi: 10.1093/infdis/jix224. [Epub ahead of print]
[h=1]Mechanism of human influenza virus RNA persistence and virion survival in feces: mucus protects virions from acid and digestive juices.[/h] Hirose R[SUP]1,[/SUP][SUP]2[/SUP], Nakaya T[SUP]2[/SUP], Naito Y[SUP]1[/SUP], Daidoji T[SUP]2[/SUP], Watanabe Y[SUP]2[/SUP], Yasuda H[SUP]1[/SUP], Konishi H[SUP]1[/SUP], Itoh Y[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Although viral RNA or infectious virions have been detected in the feces of individuals infected with human influenza A/B virus (IAV/IBV), the mechanism of viral survival in the gastrointestinal tract remains unclear. We developed a model that attempts to recapitulate the conditions encountered by a swallowed virus. While IAV/IBV is vulnerable to simulated digestive juices (gastric acid and bile/pancreatic juice), highly viscous mucus protects viral RNA and virions, allowing the virus to retain its infectivity. Our results suggest that virions and RNA present in swallowed mucus are not inactivated or degraded by the gastrointestinal environment, allowing their detection in feces.
? The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] feces; inactivation; influenza; mucus; swallow; viscosity
PMID: 28498998 DOI: 10.1093/infdis/jix224
[h=1]Mechanism of human influenza virus RNA persistence and virion survival in feces: mucus protects virions from acid and digestive juices.[/h] Hirose R[SUP]1,[/SUP][SUP]2[/SUP], Nakaya T[SUP]2[/SUP], Naito Y[SUP]1[/SUP], Daidoji T[SUP]2[/SUP], Watanabe Y[SUP]2[/SUP], Yasuda H[SUP]1[/SUP], Konishi H[SUP]1[/SUP], Itoh Y[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Although viral RNA or infectious virions have been detected in the feces of individuals infected with human influenza A/B virus (IAV/IBV), the mechanism of viral survival in the gastrointestinal tract remains unclear. We developed a model that attempts to recapitulate the conditions encountered by a swallowed virus. While IAV/IBV is vulnerable to simulated digestive juices (gastric acid and bile/pancreatic juice), highly viscous mucus protects viral RNA and virions, allowing the virus to retain its infectivity. Our results suggest that virions and RNA present in swallowed mucus are not inactivated or degraded by the gastrointestinal environment, allowing their detection in feces.
? The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] feces; inactivation; influenza; mucus; swallow; viscosity
PMID: 28498998 DOI: 10.1093/infdis/jix224