tetano
Editor, Senior Moderator
Microbiol Spectr
. 2023 Nov 17:e0302923.
doi: 10.1128/spectrum.03029-23. Online ahead of print. Nucleocapsid protein accumulates in renal tubular epithelium of a post-COVID-19 patient
Anita E Grootemaat[SUP] 1 [/SUP], Niek Wiersma[SUP] 1 [/SUP], Sanne van der Niet[SUP] 1 2 [/SUP], Irene M Schimmel[SUP] 1 [/SUP], Sandrine Florquin[SUP] 2 3 [/SUP], Eric A Reits[SUP] 1 [/SUP], Sara E Miller[SUP] 4 [/SUP], Nicole N van der Wel[SUP] 1 2 [/SUP]
Affiliations
Even though the coronavirus disease 2019 (COVID-19) pandemic is slowly developing into a conventional infectious disease, the long-term effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infection are still not well understood. One of the problems is that many COVID-19 cases develop acute kidney injuries. Still, it is heavily debated whether SARS-CoV-2 virus enters and actively replicates in kidney tissue and if SARS-CoV-2 virus particles can be detected in kidney during or post-infection. Here, we demonstrated that nucleocapsid N protein was detected in kidney tubular epithelium of patients that already recovered form COVID-19. The presence of the abundantly produced N protein without signs of viral replication could have implications for the recurrence of kidney disease and have a continuing effect on the immune system.
Keywords: SARS-CoV-2; electron microscopy; fluorescent microscopy; pathology.
. 2023 Nov 17:e0302923.
doi: 10.1128/spectrum.03029-23. Online ahead of print. Nucleocapsid protein accumulates in renal tubular epithelium of a post-COVID-19 patient
Anita E Grootemaat[SUP] 1 [/SUP], Niek Wiersma[SUP] 1 [/SUP], Sanne van der Niet[SUP] 1 2 [/SUP], Irene M Schimmel[SUP] 1 [/SUP], Sandrine Florquin[SUP] 2 3 [/SUP], Eric A Reits[SUP] 1 [/SUP], Sara E Miller[SUP] 4 [/SUP], Nicole N van der Wel[SUP] 1 2 [/SUP]
Affiliations
- PMID: 37975661
- DOI: 10.1128/spectrum.03029-23
Even though the coronavirus disease 2019 (COVID-19) pandemic is slowly developing into a conventional infectious disease, the long-term effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infection are still not well understood. One of the problems is that many COVID-19 cases develop acute kidney injuries. Still, it is heavily debated whether SARS-CoV-2 virus enters and actively replicates in kidney tissue and if SARS-CoV-2 virus particles can be detected in kidney during or post-infection. Here, we demonstrated that nucleocapsid N protein was detected in kidney tubular epithelium of patients that already recovered form COVID-19. The presence of the abundantly produced N protein without signs of viral replication could have implications for the recurrence of kidney disease and have a continuing effect on the immune system.
Keywords: SARS-CoV-2; electron microscopy; fluorescent microscopy; pathology.