tetano
Editor, Senior Moderator
J Med Microbiol. 2014 Jun 9. pii: jmm.0.067959-0. doi: 10.1099/jmm.0.067959-0. [Epub ahead of print]
MicroRNA Expression in Mice Infected with Seasonal H1N1, Swine H1N1, or Highly Pathogenic H5N1.
Vela EM1, Kasoji MD2, Wendling MQ3, Price JA3, Knostman KA3, Bresler HS3, Long JP3.
Author information
Abstract
Influenza virus infections in humans remain a health care concern and the need for vaccines, therapeutics, and prophylactics remain a high priority. Understanding of the molecular events associated with influenza virus induced pathology may lead to the description of clinical disease biomarkers and novel antiviral targets. miRNAs have role in the regulation of numerous genes and animal studies have demonstrated that miRNAs are involved in viral disease and controlling inflammation. In this study, we demonstrate differences in the miRNA expression profiles associated with the lung in mice infected with various influenza viruses that vary in virulence and pathogenicity. Additionally, this study employs a statistical model that utilizes changes in miRNA expression to identify the virus that was used to infect the mice. In all, this project identifies a unique fingerprint of viral pathogenicity associated with seasonal H1N1, swine H1N1, and highly pathogenic H5N1 in the mouse model and may lead to the identification of novel therapeutic and prophylactic targets.
Copyright ? 2014, the Society for General Microbiology.
KEYWORDS:
Gene expression; Infection models; Veterinary microbiology; Viruses
PMID:
24913561
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24913561
MicroRNA Expression in Mice Infected with Seasonal H1N1, Swine H1N1, or Highly Pathogenic H5N1.
Vela EM1, Kasoji MD2, Wendling MQ3, Price JA3, Knostman KA3, Bresler HS3, Long JP3.
Author information
Abstract
Influenza virus infections in humans remain a health care concern and the need for vaccines, therapeutics, and prophylactics remain a high priority. Understanding of the molecular events associated with influenza virus induced pathology may lead to the description of clinical disease biomarkers and novel antiviral targets. miRNAs have role in the regulation of numerous genes and animal studies have demonstrated that miRNAs are involved in viral disease and controlling inflammation. In this study, we demonstrate differences in the miRNA expression profiles associated with the lung in mice infected with various influenza viruses that vary in virulence and pathogenicity. Additionally, this study employs a statistical model that utilizes changes in miRNA expression to identify the virus that was used to infect the mice. In all, this project identifies a unique fingerprint of viral pathogenicity associated with seasonal H1N1, swine H1N1, and highly pathogenic H5N1 in the mouse model and may lead to the identification of novel therapeutic and prophylactic targets.
Copyright ? 2014, the Society for General Microbiology.
KEYWORDS:
Gene expression; Infection models; Veterinary microbiology; Viruses
PMID:
24913561
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24913561