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Mortality among patients with tuberculosis requiring intensive care: a retrospective cohort study
To describe the characteristics of patients with tuberculosis (TB) requiring intensive care and to identify the factors that predicts in-hospital mortality in a city of adeveloping country with intermediate-to-high TB endemicity.
Methods: We conducted a retrospective, cohort study, between November 2005 and November 2007. The patients with TB requiring intensive care were included.
Predictors of mortality were assessed. The primary outcome was the in-hospital mortality.
Results: During the study period, 67 patients with TB required intensive care.
Of them, 62 (92.5%) had acute respiratory failure and required mechanical ventilation. Forty-four (65.7%) patients died.
Coinfection with human immunodeficiency virus was present in 46 (68.7%) patients. Early intensive care unit admission and ventilator-associated pneumonia were independently associated with the in-hospital mortality.
Conclusions: In this study we found a high mortality rate in TB patients requiring intensive care, especially in those with an early ICU admission.
Author: Denise SilvaDiego MenegottoLuis SchulzMarcelo GazzanaPaulo Dalcin
Credits/Source: BMC Infectious Diseases 2010, 10:54
Published on: 2010-03-08
Mortality among patients with tuberculosis requiring intensive care: a retrospective cohort study
To describe the characteristics of patients with tuberculosis (TB) requiring intensive care and to identify the factors that predicts in-hospital mortality in a city of adeveloping country with intermediate-to-high TB endemicity.
Methods: We conducted a retrospective, cohort study, between November 2005 and November 2007. The patients with TB requiring intensive care were included.
Predictors of mortality were assessed. The primary outcome was the in-hospital mortality.
Results: During the study period, 67 patients with TB required intensive care.
Of them, 62 (92.5%) had acute respiratory failure and required mechanical ventilation. Forty-four (65.7%) patients died.
Coinfection with human immunodeficiency virus was present in 46 (68.7%) patients. Early intensive care unit admission and ventilator-associated pneumonia were independently associated with the in-hospital mortality.
Conclusions: In this study we found a high mortality rate in TB patients requiring intensive care, especially in those with an early ICU admission.
Author: Denise SilvaDiego MenegottoLuis SchulzMarcelo GazzanaPaulo Dalcin
Credits/Source: BMC Infectious Diseases 2010, 10:54
Published on: 2010-03-08