tetano
Editor, Senior Moderator
Mult Scler
. 2021 Sep 30;13524585211040222.
doi: 10.1177/13524585211040222. Online ahead of print.
ADEM after ChAdOx1 nCoV-19 vaccine: A case report
Virginia Rinaldi[SUP] 1 [/SUP], Gianmarco Bellucci[SUP] 1 [/SUP], Andrea Romano[SUP] 2 [/SUP], Alessandro Bozzao[SUP] 2 [/SUP], Marco Salvetti[SUP] 3 4 [/SUP]
Affiliations
Abstract
Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system (CNS), clinically defined by an acute polyfocal neurological syndrome usually with monophasic course. ADEM often occurs after infections, but 5%-10% of cases are preceded by vaccinations. Several cases of ADEM have been described after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, whereas no case has been reported after adenovirus-vectored or mRNA COVID-19 vaccine administration. Here we describe a case of ADEM presenting 2 weeks after receiving the first dose of ChAdOx1 nCoV-19 vaccine. Patient clinical/magnetic resonance imaging (MRI) status spontaneously improved and rapidly resolved with corticosteroids. A 4-month follow-up showed complete recovery and no relapses.
Keywords: ADEM; COVID-19; ChAdOx1 nCoV-19; SARS-CoV-2; vaccine.
. 2021 Sep 30;13524585211040222.
doi: 10.1177/13524585211040222. Online ahead of print.
ADEM after ChAdOx1 nCoV-19 vaccine: A case report
Virginia Rinaldi[SUP] 1 [/SUP], Gianmarco Bellucci[SUP] 1 [/SUP], Andrea Romano[SUP] 2 [/SUP], Alessandro Bozzao[SUP] 2 [/SUP], Marco Salvetti[SUP] 3 4 [/SUP]
Affiliations
- PMID: 34590902
- DOI: 10.1177/13524585211040222
Abstract
Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system (CNS), clinically defined by an acute polyfocal neurological syndrome usually with monophasic course. ADEM often occurs after infections, but 5%-10% of cases are preceded by vaccinations. Several cases of ADEM have been described after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, whereas no case has been reported after adenovirus-vectored or mRNA COVID-19 vaccine administration. Here we describe a case of ADEM presenting 2 weeks after receiving the first dose of ChAdOx1 nCoV-19 vaccine. Patient clinical/magnetic resonance imaging (MRI) status spontaneously improved and rapidly resolved with corticosteroids. A 4-month follow-up showed complete recovery and no relapses.
Keywords: ADEM; COVID-19; ChAdOx1 nCoV-19; SARS-CoV-2; vaccine.