tetano
Editor, Senior Moderator
Hum Genet. 2019 Nov 26. doi: 10.1007/s00439-019-02092-8. [Epub ahead of print] [h=1]Mx genes: host determinants controlling influenza virus infection and trans-species transmission.[/h]
Haller O[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Kochs G[SUP]4,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h] 1 Institute of Virology, Medical Center, University of Freiburg, Freiburg, Germany. otto.haller@uniklinik-freiburg.de. 2 Faculty of Medicine, University of Freiburg, Freiburg, Germany. otto.haller@uniklinik-freiburg.de. 3 Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. otto.haller@uniklinik-freiburg.de. 4 Institute of Virology, Medical Center, University of Freiburg, Freiburg, Germany. 5 Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[h=3]Abstract[/h] The human MxA protein, encoded by the interferon-inducible MX1 gene, is an intracellular influenza A virus (IAV) restriction factor. It can protect transgenic mice from severe IAV-induced disease, indicating a key role of human MxA for host survival and suggesting that natural variations in MX1 may account for inter-individual differences in disease severity among humans. MxA also provides a robust barrier against zoonotic transmissions of avian and swine IAV strains. Therefore, zoonotic IAV must acquire MxA escape mutations to achieve sustained human-to-human transmission. Here, we discuss recent progress in the field.
PMID: 31773252 DOI: 10.1007/s00439-019-02092-8
Haller O[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Kochs G[SUP]4,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h] 1 Institute of Virology, Medical Center, University of Freiburg, Freiburg, Germany. otto.haller@uniklinik-freiburg.de. 2 Faculty of Medicine, University of Freiburg, Freiburg, Germany. otto.haller@uniklinik-freiburg.de. 3 Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. otto.haller@uniklinik-freiburg.de. 4 Institute of Virology, Medical Center, University of Freiburg, Freiburg, Germany. 5 Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[h=3]Abstract[/h] The human MxA protein, encoded by the interferon-inducible MX1 gene, is an intracellular influenza A virus (IAV) restriction factor. It can protect transgenic mice from severe IAV-induced disease, indicating a key role of human MxA for host survival and suggesting that natural variations in MX1 may account for inter-individual differences in disease severity among humans. MxA also provides a robust barrier against zoonotic transmissions of avian and swine IAV strains. Therefore, zoonotic IAV must acquire MxA escape mutations to achieve sustained human-to-human transmission. Here, we discuss recent progress in the field.
PMID: 31773252 DOI: 10.1007/s00439-019-02092-8