tetano
Editor, Senior Moderator
Nat Aging
. 2024 Jun 25.
doi: 10.1038/s43587-024-00644-w. Online ahead of print. Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19
Beatrice Dallan[SUP] #[/SUP][SUP] 1 [/SUP], Davide Proietto[SUP] #[/SUP][SUP] 1 [/SUP], Martina De Laurentis[SUP] 1 [/SUP], Eleonora Gallerani[SUP] 1 [/SUP], Mara Martino[SUP] 1 [/SUP], Sara Ghisellini[SUP] 2 [/SUP], Amedeo Zurlo[SUP] 3 [/SUP], Stefano Volpato[SUP] 3 [/SUP], Benedetta Govoni[SUP] 3 [/SUP], Michela Borghesi[SUP] 4 [/SUP], Valentina Albanese[SUP] 5 [/SUP], Victor Appay[SUP] 6 [/SUP], Stefano Bonnini[SUP] 4 [/SUP], Sian Llewellyn-Lacey[SUP] 7 [/SUP], Salvatore Pacifico[SUP] 1 [/SUP], Laura Grumiro[SUP] 8 [/SUP], Martina Brandolini[SUP] 8 [/SUP], Simona Semprini[SUP] 9 [/SUP], Vittorio Sambri[SUP] 8 9 [/SUP], Kristin Ladell[SUP] 7 [/SUP], Helen M Parry[SUP] 10 [/SUP], Paul A H Moss[SUP] 10 [/SUP], David A Price[SUP] 7 11 [/SUP]; RIV Study Group; Antonella Caputo[SUP] 1 [/SUP], Riccardo Gavioli[SUP] 1 [/SUP], Francesco Nicoli[SUP] 12 [/SUP]
Collaborators, Affiliations
Adenoviral and mRNA vaccines encoding the viral spike (S) protein have been deployed globally to contain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Older individuals are particularly vulnerable to severe infection, probably reflecting age-related changes in the immune system, which can also compromise vaccine efficacy. It is nonetheless unclear to what extent different vaccine platforms are impacted by immunosenescence. Here, we evaluated S protein-specific immune responses elicited by vaccination with two doses of BNT162b2 or ChAdOx1-S and subsequently boosted with a single dose of BNT162b2 or mRNA-1273, comparing age-stratified participants with no evidence of previous infection with SARS-CoV-2. We found that aging profoundly compromised S protein-specific IgG titers and further limited S protein-specific CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T cell immunity as a probable function of progressive erosion of the naive lymphocyte pool in individuals vaccinated initially with BNT162b2. Our results demonstrate that primary vaccination with ChAdOx1-S and subsequent boosting with BNT162b2 or mRNA-1273 promotes sustained immunological memory in older adults and potentially confers optimal protection against coronavirus disease 2019.
. 2024 Jun 25.
doi: 10.1038/s43587-024-00644-w. Online ahead of print. Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19
Beatrice Dallan[SUP] #[/SUP][SUP] 1 [/SUP], Davide Proietto[SUP] #[/SUP][SUP] 1 [/SUP], Martina De Laurentis[SUP] 1 [/SUP], Eleonora Gallerani[SUP] 1 [/SUP], Mara Martino[SUP] 1 [/SUP], Sara Ghisellini[SUP] 2 [/SUP], Amedeo Zurlo[SUP] 3 [/SUP], Stefano Volpato[SUP] 3 [/SUP], Benedetta Govoni[SUP] 3 [/SUP], Michela Borghesi[SUP] 4 [/SUP], Valentina Albanese[SUP] 5 [/SUP], Victor Appay[SUP] 6 [/SUP], Stefano Bonnini[SUP] 4 [/SUP], Sian Llewellyn-Lacey[SUP] 7 [/SUP], Salvatore Pacifico[SUP] 1 [/SUP], Laura Grumiro[SUP] 8 [/SUP], Martina Brandolini[SUP] 8 [/SUP], Simona Semprini[SUP] 9 [/SUP], Vittorio Sambri[SUP] 8 9 [/SUP], Kristin Ladell[SUP] 7 [/SUP], Helen M Parry[SUP] 10 [/SUP], Paul A H Moss[SUP] 10 [/SUP], David A Price[SUP] 7 11 [/SUP]; RIV Study Group; Antonella Caputo[SUP] 1 [/SUP], Riccardo Gavioli[SUP] 1 [/SUP], Francesco Nicoli[SUP] 12 [/SUP]
Collaborators, Affiliations
- PMID: 38918602
- DOI: 10.1038/s43587-024-00644-w
Adenoviral and mRNA vaccines encoding the viral spike (S) protein have been deployed globally to contain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Older individuals are particularly vulnerable to severe infection, probably reflecting age-related changes in the immune system, which can also compromise vaccine efficacy. It is nonetheless unclear to what extent different vaccine platforms are impacted by immunosenescence. Here, we evaluated S protein-specific immune responses elicited by vaccination with two doses of BNT162b2 or ChAdOx1-S and subsequently boosted with a single dose of BNT162b2 or mRNA-1273, comparing age-stratified participants with no evidence of previous infection with SARS-CoV-2. We found that aging profoundly compromised S protein-specific IgG titers and further limited S protein-specific CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T cell immunity as a probable function of progressive erosion of the naive lymphocyte pool in individuals vaccinated initially with BNT162b2. Our results demonstrate that primary vaccination with ChAdOx1-S and subsequent boosting with BNT162b2 or mRNA-1273 promotes sustained immunological memory in older adults and potentially confers optimal protection against coronavirus disease 2019.