tetano
Editor, Senior Moderator
Nat Commun
. 2024 Apr 25;15(1):3449.
doi: 10.1038/s41467-024-47635-4. Cross-species spill-over potential of the H9N2 bat influenza A virus
Rabeh El-Shesheny[SUP] 1 [/SUP], John Franks[SUP] 2 [/SUP], Ahmed Kandeil[SUP] 1 2 [/SUP], Rebecca Badra[SUP] 3 [/SUP], Jasmine Turner[SUP] 2 [/SUP], Patrick Seiler[SUP] 2 [/SUP], Bindumadhav M Marathe[SUP] 2 [/SUP], Trushar Jeevan[SUP] 2 [/SUP], Lisa Kercher[SUP] 2 [/SUP], Meng Hu[SUP] 2 [/SUP], Yul Eum Sim[SUP] 4 [/SUP], Kenrie P Y Hui[SUP] 5 [/SUP], Michael C W Chan[SUP] 5 [/SUP], Andrew J Thompson[SUP] 6 [/SUP], Pamela McKenzie[SUP] 2 [/SUP], Elena A Govorkova[SUP] 2 [/SUP], Charles J Russell[SUP] 2 [/SUP], Peter Vogel[SUP] 2 [/SUP], James C Paulson[SUP] 6 [/SUP], J S Malik Peiris[SUP] 5 [/SUP], Robert G Webster[SUP] 2 [/SUP], Mohamed A Ali[SUP] 1 [/SUP], Ghazi Kayali[SUP] 7 [/SUP], Richard J Webby[SUP] 8 [/SUP]
Affiliations
In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bird-to-bat transmission event. To determine the cross-species spill-over potential, we biologically characterize features of A/bat/Egypt/381OP/2017(H9N2). The virus has a pH inactivation profile and neuraminidase activity similar to those of human-adapted IAVs. Despite the virus having an avian virus-like preference for α2,3 sialic acid receptors, it is unable to replicate in male mallard ducks; however, it readily infects ex-vivo human respiratory cell cultures and replicates in the lungs of female mice. A/bat/Egypt/381OP/2017 replicates in the upper respiratory tract of experimentally-infected male ferrets featuring direct-contact and airborne transmission. These data suggest that the bat A(H9N2) virus has features associated with increased risk to humans without a shift to a preference for α2,6 sialic acid receptors.
. 2024 Apr 25;15(1):3449.
doi: 10.1038/s41467-024-47635-4. Cross-species spill-over potential of the H9N2 bat influenza A virus
Rabeh El-Shesheny[SUP] 1 [/SUP], John Franks[SUP] 2 [/SUP], Ahmed Kandeil[SUP] 1 2 [/SUP], Rebecca Badra[SUP] 3 [/SUP], Jasmine Turner[SUP] 2 [/SUP], Patrick Seiler[SUP] 2 [/SUP], Bindumadhav M Marathe[SUP] 2 [/SUP], Trushar Jeevan[SUP] 2 [/SUP], Lisa Kercher[SUP] 2 [/SUP], Meng Hu[SUP] 2 [/SUP], Yul Eum Sim[SUP] 4 [/SUP], Kenrie P Y Hui[SUP] 5 [/SUP], Michael C W Chan[SUP] 5 [/SUP], Andrew J Thompson[SUP] 6 [/SUP], Pamela McKenzie[SUP] 2 [/SUP], Elena A Govorkova[SUP] 2 [/SUP], Charles J Russell[SUP] 2 [/SUP], Peter Vogel[SUP] 2 [/SUP], James C Paulson[SUP] 6 [/SUP], J S Malik Peiris[SUP] 5 [/SUP], Robert G Webster[SUP] 2 [/SUP], Mohamed A Ali[SUP] 1 [/SUP], Ghazi Kayali[SUP] 7 [/SUP], Richard J Webby[SUP] 8 [/SUP]
Affiliations
- PMID: 38664384
- DOI: 10.1038/s41467-024-47635-4
In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bird-to-bat transmission event. To determine the cross-species spill-over potential, we biologically characterize features of A/bat/Egypt/381OP/2017(H9N2). The virus has a pH inactivation profile and neuraminidase activity similar to those of human-adapted IAVs. Despite the virus having an avian virus-like preference for α2,3 sialic acid receptors, it is unable to replicate in male mallard ducks; however, it readily infects ex-vivo human respiratory cell cultures and replicates in the lungs of female mice. A/bat/Egypt/381OP/2017 replicates in the upper respiratory tract of experimentally-infected male ferrets featuring direct-contact and airborne transmission. These data suggest that the bat A(H9N2) virus has features associated with increased risk to humans without a shift to a preference for α2,6 sialic acid receptors.