tetano
Editor, Senior Moderator
Nat Immunol. 2017 Sep 11. doi: 10.1038/ni.3837. [Epub ahead of print]
[h=1]Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection.[/h] Botta D[SUP]1[/SUP], Fuller MJ[SUP]2[/SUP], Marquez-Lago TT[SUP]3,[/SUP][SUP]4[/SUP], Bachus H[SUP]2[/SUP], Bradley JE[SUP]2[/SUP], Weinmann AS[SUP]1[/SUP], Zajac AJ[SUP]1[/SUP], Randall TD[SUP]2[/SUP], Lund FE[SUP]1[/SUP], Le?n B[SUP]1[/SUP], Ballesteros-Tato A[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Interleukin 2 (IL-2) promotes Foxp3[SUP]+[/SUP] regulatory T (T[SUB]reg[/SUB]) cell responses, but inhibits T follicular helper (T[SUB]FH[/SUB]) cell development. However, it is not clear how IL-2 affects T follicular regulatory (T[SUB]FR[/SUB]) cells, a cell type with properties of both T[SUB]reg[/SUB] and T[SUB]FH[/SUB] cells. Using an influenza infection model, we found that high IL-2 concentrations at the peak of the infection prevented T[SUB]FR[/SUB] cell development by a Blimp-1-dependent mechanism. However, once the immune response resolved, some T[SUB]reg[/SUB] cells downregulated CD25, upregulated Bcl-6 and differentiated into T[SUB]FR[/SUB] cells, which then migrated into the B cell follicles to prevent the expansion of self-reactive B cell clones. Thus, unlike its effects on conventional T[SUB]reg[/SUB] cells, IL-2 inhibits T[SUB]FR[/SUB] cell responses.
PMID: 28892471 DOI: 10.1038/ni.3837
[h=1]Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection.[/h] Botta D[SUP]1[/SUP], Fuller MJ[SUP]2[/SUP], Marquez-Lago TT[SUP]3,[/SUP][SUP]4[/SUP], Bachus H[SUP]2[/SUP], Bradley JE[SUP]2[/SUP], Weinmann AS[SUP]1[/SUP], Zajac AJ[SUP]1[/SUP], Randall TD[SUP]2[/SUP], Lund FE[SUP]1[/SUP], Le?n B[SUP]1[/SUP], Ballesteros-Tato A[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Interleukin 2 (IL-2) promotes Foxp3[SUP]+[/SUP] regulatory T (T[SUB]reg[/SUB]) cell responses, but inhibits T follicular helper (T[SUB]FH[/SUB]) cell development. However, it is not clear how IL-2 affects T follicular regulatory (T[SUB]FR[/SUB]) cells, a cell type with properties of both T[SUB]reg[/SUB] and T[SUB]FH[/SUB] cells. Using an influenza infection model, we found that high IL-2 concentrations at the peak of the infection prevented T[SUB]FR[/SUB] cell development by a Blimp-1-dependent mechanism. However, once the immune response resolved, some T[SUB]reg[/SUB] cells downregulated CD25, upregulated Bcl-6 and differentiated into T[SUB]FR[/SUB] cells, which then migrated into the B cell follicles to prevent the expansion of self-reactive B cell clones. Thus, unlike its effects on conventional T[SUB]reg[/SUB] cells, IL-2 inhibits T[SUB]FR[/SUB] cell responses.
PMID: 28892471 DOI: 10.1038/ni.3837