tetano
Editor, Senior Moderator
Nat Med
. 2021 Mar 22.
doi: 10.1038/s41591-021-01283-z. Online ahead of print.
Post-acute COVID-19 syndrome
Ani Nalbandian[SUP] #[/SUP][SUP] 1 [/SUP], Kartik Sehgal[SUP] #[/SUP][SUP] 2 3 4 [/SUP], Aakriti Gupta[SUP] 1 5 6 [/SUP], Mahesh V Madhavan[SUP] 1 5 [/SUP], Claire McGroder[SUP] 7 [/SUP], Jacob S Stevens[SUP] 8 [/SUP], Joshua R Cook[SUP] 9 [/SUP], Anna S Nordvig[SUP] 10 [/SUP], Daniel Shalev[SUP] 11 [/SUP], Tejasav S Sehrawat[SUP] 12 [/SUP], Neha Ahluwalia[SUP] 13 [/SUP], Behnood Bikdeli[SUP] 14 5 6 15 [/SUP], Donald Dietz[SUP] 16 [/SUP], Caroline Der-Nigoghossian[SUP] 17 [/SUP], Nadia Liyanage-Don[SUP] 18 [/SUP], Gregg F Rosner[SUP] 1 [/SUP], Elana J Bernstein[SUP] 19 [/SUP], Sumit Mohan[SUP] 8 [/SUP], Akinpelumi A Beckley[SUP] 20 [/SUP], David S Seres[SUP] 21 [/SUP], Toni K Choueiri[SUP] 22 23 14 [/SUP], Nir Uriel[SUP] 1 [/SUP], John C Ausiello[SUP] 9 [/SUP], Domenico Accili[SUP] 9 [/SUP], Daniel E Freedberg[SUP] 24 [/SUP], Matthew Baldwin[SUP] 7 [/SUP], Allan Schwartz[SUP] 1 [/SUP], Daniel Brodie[SUP] 7 [/SUP], Christine Kim Garcia[SUP] 7 [/SUP], Mitchell S V Elkind[SUP] 10 25 [/SUP], Jean M Connors[SUP] 14 26 [/SUP], John P Bilezikian[SUP] 9 [/SUP], Donald W Landry[SUP] 8 [/SUP], Elaine Y Wan[SUP] 27 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients recovering from COVID-19 grows, it is paramount to establish an understanding of the healthcare issues surrounding them. COVID-19 is now recognized as a multi-organ disease with a broad spectrum of manifestations. Similarly to post-acute viral syndromes described in survivors of other virulent coronavirus epidemics, there are increasing reports of persistent and prolonged effects after acute COVID-19. Patient advocacy groups, many members of which identify themselves as long haulers, have helped contribute to the recognition of post-acute COVID-19, a syndrome characterized by persistent symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms. Here, we provide a comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae. Finally, we discuss relevant considerations for the multidisciplinary care of COVID-19 survivors and propose a framework for the identification of those at high risk for post-acute COVID-19 and their coordinated management through dedicated COVID-19 clinics.
. 2021 Mar 22.
doi: 10.1038/s41591-021-01283-z. Online ahead of print.
Post-acute COVID-19 syndrome
Ani Nalbandian[SUP] #[/SUP][SUP] 1 [/SUP], Kartik Sehgal[SUP] #[/SUP][SUP] 2 3 4 [/SUP], Aakriti Gupta[SUP] 1 5 6 [/SUP], Mahesh V Madhavan[SUP] 1 5 [/SUP], Claire McGroder[SUP] 7 [/SUP], Jacob S Stevens[SUP] 8 [/SUP], Joshua R Cook[SUP] 9 [/SUP], Anna S Nordvig[SUP] 10 [/SUP], Daniel Shalev[SUP] 11 [/SUP], Tejasav S Sehrawat[SUP] 12 [/SUP], Neha Ahluwalia[SUP] 13 [/SUP], Behnood Bikdeli[SUP] 14 5 6 15 [/SUP], Donald Dietz[SUP] 16 [/SUP], Caroline Der-Nigoghossian[SUP] 17 [/SUP], Nadia Liyanage-Don[SUP] 18 [/SUP], Gregg F Rosner[SUP] 1 [/SUP], Elana J Bernstein[SUP] 19 [/SUP], Sumit Mohan[SUP] 8 [/SUP], Akinpelumi A Beckley[SUP] 20 [/SUP], David S Seres[SUP] 21 [/SUP], Toni K Choueiri[SUP] 22 23 14 [/SUP], Nir Uriel[SUP] 1 [/SUP], John C Ausiello[SUP] 9 [/SUP], Domenico Accili[SUP] 9 [/SUP], Daniel E Freedberg[SUP] 24 [/SUP], Matthew Baldwin[SUP] 7 [/SUP], Allan Schwartz[SUP] 1 [/SUP], Daniel Brodie[SUP] 7 [/SUP], Christine Kim Garcia[SUP] 7 [/SUP], Mitchell S V Elkind[SUP] 10 25 [/SUP], Jean M Connors[SUP] 14 26 [/SUP], John P Bilezikian[SUP] 9 [/SUP], Donald W Landry[SUP] 8 [/SUP], Elaine Y Wan[SUP] 27 [/SUP]
Affiliations
- PMID: 33753937
- DOI: 10.1038/s41591-021-01283-z
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients recovering from COVID-19 grows, it is paramount to establish an understanding of the healthcare issues surrounding them. COVID-19 is now recognized as a multi-organ disease with a broad spectrum of manifestations. Similarly to post-acute viral syndromes described in survivors of other virulent coronavirus epidemics, there are increasing reports of persistent and prolonged effects after acute COVID-19. Patient advocacy groups, many members of which identify themselves as long haulers, have helped contribute to the recognition of post-acute COVID-19, a syndrome characterized by persistent symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms. Here, we provide a comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae. Finally, we discuss relevant considerations for the multidisciplinary care of COVID-19 survivors and propose a framework for the identification of those at high risk for post-acute COVID-19 and their coordinated management through dedicated COVID-19 clinics.