tetano
Editor, Senior Moderator
Neurol Sci
. 2021 May 5.
doi: 10.1007/s10072-021-05299-8. Online ahead of print.
The relationship between COVID-19's severity and ischemic stroke: a systematic review and meta-analysis
Yue Lu[SUP] #[/SUP][SUP] 1 [/SUP], Jie-Ji Zhao[SUP] #[/SUP][SUP] 1 [/SUP], Meng-Fan Ye[SUP] 1 [/SUP], Hong-Mei Li[SUP] 1 [/SUP], Fei-Rong Yao[SUP] 2 [/SUP], Yan Kong[SUP] 3 [/SUP], Zhuan Xu[SUP] 4 [/SUP]
Affiliations
Abstract
Objective: We aim to determine the risk of acute ischemic stroke in patients with severe and non-severe coronavirus disease 2019 (COVID-19).
Methods: A literature search was conducted in the PubMed, Embase, Web of Science, and Cochrane Library databases until October 28, 2020. Studies covering COVID-19's severity classification data and COVID-19 patients with acute ischemic stroke were included. Two independent evaluators extracted data, and the random effects model was used to calculate the risk ratios (RR) and 95% confidence interval (95% CI) of acute ischemic stroke associated with COVID-19's severity.
Results: A total of 8 studies were included, involving 5266 patients. Among all COVID-19 patients, the total incidence of ischemic stroke was 1.76% (95% CI: 0.82-3.01). Severe patients have an increased risk of acute ischemic stroke compared with non-severe patients (RR = 3.53, 95% CI: 2.06-6.07, P < 0.0001; I[SUP]2[/SUP] = 12%). This association was also observed when COVID-19's severity was defined by clinical parameters (RR 2.91, 95% CI: 1.17-7.26, P = 0.02; I[SUP]2[/SUP] = 29%) and the need for intensive care (RR 4.47, 95% CI: 2.40-8.31, P < 0.0001; I[SUP]2[/SUP] = 0%).
Conclusions: This meta-analysis shows that the severe course of COVID-19 is associated with an increased risk of acute ischemic stroke.
Keywords: COVID-19; Ischemic stroke; Meta-analysis; Severity.
. 2021 May 5.
doi: 10.1007/s10072-021-05299-8. Online ahead of print.
The relationship between COVID-19's severity and ischemic stroke: a systematic review and meta-analysis
Yue Lu[SUP] #[/SUP][SUP] 1 [/SUP], Jie-Ji Zhao[SUP] #[/SUP][SUP] 1 [/SUP], Meng-Fan Ye[SUP] 1 [/SUP], Hong-Mei Li[SUP] 1 [/SUP], Fei-Rong Yao[SUP] 2 [/SUP], Yan Kong[SUP] 3 [/SUP], Zhuan Xu[SUP] 4 [/SUP]
Affiliations
- PMID: 33954827
- DOI: 10.1007/s10072-021-05299-8
Abstract
Objective: We aim to determine the risk of acute ischemic stroke in patients with severe and non-severe coronavirus disease 2019 (COVID-19).
Methods: A literature search was conducted in the PubMed, Embase, Web of Science, and Cochrane Library databases until October 28, 2020. Studies covering COVID-19's severity classification data and COVID-19 patients with acute ischemic stroke were included. Two independent evaluators extracted data, and the random effects model was used to calculate the risk ratios (RR) and 95% confidence interval (95% CI) of acute ischemic stroke associated with COVID-19's severity.
Results: A total of 8 studies were included, involving 5266 patients. Among all COVID-19 patients, the total incidence of ischemic stroke was 1.76% (95% CI: 0.82-3.01). Severe patients have an increased risk of acute ischemic stroke compared with non-severe patients (RR = 3.53, 95% CI: 2.06-6.07, P < 0.0001; I[SUP]2[/SUP] = 12%). This association was also observed when COVID-19's severity was defined by clinical parameters (RR 2.91, 95% CI: 1.17-7.26, P = 0.02; I[SUP]2[/SUP] = 29%) and the need for intensive care (RR 4.47, 95% CI: 2.40-8.31, P < 0.0001; I[SUP]2[/SUP] = 0%).
Conclusions: This meta-analysis shows that the severe course of COVID-19 is associated with an increased risk of acute ischemic stroke.
Keywords: COVID-19; Ischemic stroke; Meta-analysis; Severity.