tetano
Editor, Senior Moderator
J Infect Dis. 2018 Dec 9. doi: 10.1093/infdis/jiy700. [Epub ahead of print]
[h=1]Obesity-induced changes in T cell metabolism are associated with impaired memory T cell response to influenza and are not reversed with weight loss.[/h] Jennifer R[SUP]1[/SUP], Green WD[SUP]1[/SUP], Alwarawrah Y[SUP]2[/SUP], Nichols AG[SUP]2[/SUP], Eisner W[SUP]2[/SUP], Danzaki K[SUP]2[/SUP], MacIver NJ[SUP]2[/SUP], Beck MA[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Obesity is an independent risk factor for increased influenza mortality and is associated with impaired memory T cell response, resulting in increased risk of infection. In this study, we investigated if weight loss would restore memory T cell response to influenza.
[h=4]Methods:[/h] Male C57BL/6J mice were fed either low-fat or high-fat diet to induce obesity. Once obesity was established, all mice received primary infection with influenza X-31. Following a recovery period, we switched half of the obese group to a low-fat diet to induce weight loss. Fifteen weeks after diet switch, all mice were given a secondary infection with influenza PR8, and memory T cell function and T cell metabolism were measured.
[h=4]Results:[/h] Following secondary influenza infection, memory T cell subsets in the lungs of obese mice were decreased compared to lean mice. At the same time, T cells from obese mice were found to have altered cellular metabolism, largely characterized by an increase in oxygen consumption. Neither impaired memory T cell response nor altered T cell metabolism was reversed with weight loss.
[h=4]Conclusion:[/h] Obesity-associated changes in T cell metabolism are associated with impaired T cell response to influenza, and are not reversed with weight loss.
PMID: 30535161 DOI: 10.1093/infdis/jiy700
[h=1]Obesity-induced changes in T cell metabolism are associated with impaired memory T cell response to influenza and are not reversed with weight loss.[/h] Jennifer R[SUP]1[/SUP], Green WD[SUP]1[/SUP], Alwarawrah Y[SUP]2[/SUP], Nichols AG[SUP]2[/SUP], Eisner W[SUP]2[/SUP], Danzaki K[SUP]2[/SUP], MacIver NJ[SUP]2[/SUP], Beck MA[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Obesity is an independent risk factor for increased influenza mortality and is associated with impaired memory T cell response, resulting in increased risk of infection. In this study, we investigated if weight loss would restore memory T cell response to influenza.
[h=4]Methods:[/h] Male C57BL/6J mice were fed either low-fat or high-fat diet to induce obesity. Once obesity was established, all mice received primary infection with influenza X-31. Following a recovery period, we switched half of the obese group to a low-fat diet to induce weight loss. Fifteen weeks after diet switch, all mice were given a secondary infection with influenza PR8, and memory T cell function and T cell metabolism were measured.
[h=4]Results:[/h] Following secondary influenza infection, memory T cell subsets in the lungs of obese mice were decreased compared to lean mice. At the same time, T cells from obese mice were found to have altered cellular metabolism, largely characterized by an increase in oxygen consumption. Neither impaired memory T cell response nor altered T cell metabolism was reversed with weight loss.
[h=4]Conclusion:[/h] Obesity-associated changes in T cell metabolism are associated with impaired T cell response to influenza, and are not reversed with weight loss.
PMID: 30535161 DOI: 10.1093/infdis/jiy700