tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2020 Nov 3;8(1)
faa521.
doi: 10.1093/ofid/ofaa521. eCollection 2021 Jan.
Neopterin Predicts Disease Severity in Hospitalized Patients With COVID-19
Rosa Bellmann-Weiler[SUP] 1 [/SUP], Lukas Lanser[SUP] 1 [/SUP], Francesco Burkert[SUP] 1 [/SUP], Stefanie Seiwald[SUP] 1 [/SUP], Gernot Fritsche[SUP] 1 [/SUP], Sophie Wildner[SUP] 1 [/SUP], Andrea Schroll[SUP] 1 [/SUP], Sabine Koppelst?tter[SUP] 1 [/SUP], Katharina Kurz[SUP] 1 [/SUP], Andrea Griesmacher[SUP] 2 [/SUP], G?nter Weiss[SUP] 1 [/SUP]
Affiliations
Abstract
This study evaluates the predictive value of circulating inflammatory markers, especially neopterin, in patients with coronavirus disease 2019 (COVID-19). Within this retrospective analysis of 115 hospitalized COVID-19 patients, elevated neopterin levels upon admission were significantly associated with disease severity, risk for intensive care unit admission, need for mechanical ventilation, and death. Therefore, neopterin is a reliable predictive marker in patients with COVID-19 and may help to improve the clinical management of patients.
Keywords: COVID-19; SARS-CoV-2; disease severity; neopterin; outcome.
. 2020 Nov 3;8(1)
faa521.doi: 10.1093/ofid/ofaa521. eCollection 2021 Jan.
Neopterin Predicts Disease Severity in Hospitalized Patients With COVID-19
Rosa Bellmann-Weiler[SUP] 1 [/SUP], Lukas Lanser[SUP] 1 [/SUP], Francesco Burkert[SUP] 1 [/SUP], Stefanie Seiwald[SUP] 1 [/SUP], Gernot Fritsche[SUP] 1 [/SUP], Sophie Wildner[SUP] 1 [/SUP], Andrea Schroll[SUP] 1 [/SUP], Sabine Koppelst?tter[SUP] 1 [/SUP], Katharina Kurz[SUP] 1 [/SUP], Andrea Griesmacher[SUP] 2 [/SUP], G?nter Weiss[SUP] 1 [/SUP]
Affiliations
- PMID: 33442554
- PMCID: PMC7665702
- DOI: 10.1093/ofid/ofaa521
Abstract
This study evaluates the predictive value of circulating inflammatory markers, especially neopterin, in patients with coronavirus disease 2019 (COVID-19). Within this retrospective analysis of 115 hospitalized COVID-19 patients, elevated neopterin levels upon admission were significantly associated with disease severity, risk for intensive care unit admission, need for mechanical ventilation, and death. Therefore, neopterin is a reliable predictive marker in patients with COVID-19 and may help to improve the clinical management of patients.
Keywords: COVID-19; SARS-CoV-2; disease severity; neopterin; outcome.