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Oseltamivir-zanamivir combination therapy is not superior to zanamivir monotherapy in mice infected with influenza A(H3N2) and A(H1N1)pdm09 viruses

tetano

tetano

Editor, Senior Moderator
Antiviral Res. 2014 Feb 27. pii: S0166-3542(14)00060-6. doi: 10.1016/j.antiviral.2014.02.017. [Epub ahead of print]
Oseltamivir-zanamivir combination therapy is not superior to zanamivir monotherapy in mice infected with influenza A(H3N2) and A(H1N1)pdm09 viruses.
Pizzorno A1, Abed Y1, Rh?aume C1, Boivin G2.
Author information
Abstract

The efficacy of oseltamivir-zanamivir combination therapy compared to that of monotherapy was evaluated in mice infected with influenza A(H3N2) or A(H1N1)pdm09 viruses. For A(H3N2) virus, zanamivir monotherapy and oseltamivir-zanamivir combination showed significant reduction of mean weight loss compared to oseltamivir. Zanamivir monotherapy also conferred decreased mortality, weight loss and lung viral titers (LVT) compared to oseltamivir for A(H1N1)pdm09 wild-type virus. Intermediate benefits were observed for the oseltamivir-zanamivir combination. For the oseltamivir-resistant A(H1N1)pdm09 H275Y virus, the efficacy of oseltamivir-zanamivir was comparable to that of zanamivir and significantly higher than that of oseltamivir in terms of survival, weight loss and LVT.

Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:

Combination, Influenza, Neuraminidase inhibitors, Oseltamivir, Resistance, Zanamivir

PMID:
24583158
[PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24583158
 
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