tetano
Editor, Senior Moderator
J Heart Lung Transplant. 2010 Jun 15. [Epub ahead of print]
Pandemic influenza (H1N1): Impact on lung transplant recipients and candidates.
Fox BD, Raviv Y, Rozengarten D, Rusanov V, Bakal I, Kramer MR.
Pulmonary Institute, Rabin Medical Center, Beilinson Campus, Petach Tiqwa, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Abstract
BACKGROUND: The year 2009 was notable for the outbreak of a novel strain of influenza A (H1N1). We report the outcomes of H1N1 infection in a large cohort of lung transplant (LTx) recipients and candidates. METHODS: This was a retrospective review of 22 suspected cases of H1N1 influenza screened using real-time polymerase chain reaction from nasal secretions. There were 15 confirmed cases (10 LTx recipients, 5 LTx candidates). RESULTS: All patients were treated with oseltamivir at the time of the first clinical assessment. In the LTx recipients group, 7 of the 10 confirmed cases were treated at home with oseltamivir alone. Three patients were admitted with complications (2 pneumonia, 1 acute rejection). Two patients required mechanical ventilation. Two patients had prolonged viral shedding. No deaths occurred among the LTx recipients. In the 5 LTx candidates with confirmed H1N1, 2 deaths occurred from pneumonia and acute respiratory distress syndrome. CONCLUSIONS: Influenza H1N1 had a significant complication rate amongst LTx recipients and a high mortality rate amongst LTx candidates. Copyright ? 2010 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
PMID: 20558087 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20558087
Pandemic influenza (H1N1): Impact on lung transplant recipients and candidates.
Fox BD, Raviv Y, Rozengarten D, Rusanov V, Bakal I, Kramer MR.
Pulmonary Institute, Rabin Medical Center, Beilinson Campus, Petach Tiqwa, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Abstract
BACKGROUND: The year 2009 was notable for the outbreak of a novel strain of influenza A (H1N1). We report the outcomes of H1N1 infection in a large cohort of lung transplant (LTx) recipients and candidates. METHODS: This was a retrospective review of 22 suspected cases of H1N1 influenza screened using real-time polymerase chain reaction from nasal secretions. There were 15 confirmed cases (10 LTx recipients, 5 LTx candidates). RESULTS: All patients were treated with oseltamivir at the time of the first clinical assessment. In the LTx recipients group, 7 of the 10 confirmed cases were treated at home with oseltamivir alone. Three patients were admitted with complications (2 pneumonia, 1 acute rejection). Two patients required mechanical ventilation. Two patients had prolonged viral shedding. No deaths occurred among the LTx recipients. In the 5 LTx candidates with confirmed H1N1, 2 deaths occurred from pneumonia and acute respiratory distress syndrome. CONCLUSIONS: Influenza H1N1 had a significant complication rate amongst LTx recipients and a high mortality rate amongst LTx candidates. Copyright ? 2010 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
PMID: 20558087 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20558087