tetano
Editor, Senior Moderator
Pathogens
. 2022 Aug 22;11(8):947.
doi: 10.3390/pathogens11080947.
Angiotensin-Converting Enzyme 2 SNPs as Common Genetic Loci and Optimal Early Identification Genetic Markers for COVID-19
Yan Ma[SUP] 1 [/SUP], Qiuyue Li[SUP] 1 [/SUP], Jun Chen[SUP] 1 [/SUP], Songmei Liu[SUP] 2 [/SUP], Shanshan Liu[SUP] 1 [/SUP], Xiaomeng He[SUP] 1 [/SUP], Yun Ling[SUP] 1 [/SUP], Jianghua Zheng[SUP] 3 [/SUP], Christopher Corpe[SUP] 4 [/SUP], Hongzhou Lu[SUP] 5 [/SUP], Jin Wang[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Angiotensin-converting enzyme 2 (ACE2) is implicated as a host cell receptor that causes infection in the pathogenesis of coronavirus disease 2019 (COVID-19), and its genetic polymorphisms in the ACE2 gene may promote cardiovascular disease and systemic inflammatory injury in COVID-19 patients. Hence, the genetic background may potentially explain the broad interindividual variation in disease susceptibility and/or severity.
Methods: Genetic susceptibility to COVID-19 was analyzed by examining single-nucleotide polymorphisms (SNPs) of ACE2 in 246 patients with COVID-19 and 210 normal controls using the TaqMan genotyping assay.
Results: We demonstrated that the ACE2 SNPs rs4646142, rs6632677, and rs2074192 were associated with COVID-19 (for all, p < 0.05), and the differences in the ACE2 SNPs rs4646142 and rs6632677 were correlated with COVID-19-related systemic inflammatory injury and cardiovascular risk. Specifically, rs4646142 was associated with high-sensitivity C-reactive protein (hs-CRP), prealbumin (PAB), apolipoprotein A (APOA), high-density lipoprotein (HDL), and acid glycoprotein (AGP) levels. Rs6632677 was also associated with elevated CRP, acid glycoprotein (AGP), and haptoglobin (HPT).
Conclusions: Our results suggest that the ACE2 SNPs rs4646142 and rs6632677 may be common genetic loci and optimal early identification genetic markers for COVID-19 with cardiovascular risk.
Keywords: ACE2; COVID-19; SNP; cardiovascular risks.
. 2022 Aug 22;11(8):947.
doi: 10.3390/pathogens11080947.
Angiotensin-Converting Enzyme 2 SNPs as Common Genetic Loci and Optimal Early Identification Genetic Markers for COVID-19
Yan Ma[SUP] 1 [/SUP], Qiuyue Li[SUP] 1 [/SUP], Jun Chen[SUP] 1 [/SUP], Songmei Liu[SUP] 2 [/SUP], Shanshan Liu[SUP] 1 [/SUP], Xiaomeng He[SUP] 1 [/SUP], Yun Ling[SUP] 1 [/SUP], Jianghua Zheng[SUP] 3 [/SUP], Christopher Corpe[SUP] 4 [/SUP], Hongzhou Lu[SUP] 5 [/SUP], Jin Wang[SUP] 1 [/SUP]
Affiliations
- PMID: 36015068
- DOI: 10.3390/pathogens11080947
Abstract
Background: Angiotensin-converting enzyme 2 (ACE2) is implicated as a host cell receptor that causes infection in the pathogenesis of coronavirus disease 2019 (COVID-19), and its genetic polymorphisms in the ACE2 gene may promote cardiovascular disease and systemic inflammatory injury in COVID-19 patients. Hence, the genetic background may potentially explain the broad interindividual variation in disease susceptibility and/or severity.
Methods: Genetic susceptibility to COVID-19 was analyzed by examining single-nucleotide polymorphisms (SNPs) of ACE2 in 246 patients with COVID-19 and 210 normal controls using the TaqMan genotyping assay.
Results: We demonstrated that the ACE2 SNPs rs4646142, rs6632677, and rs2074192 were associated with COVID-19 (for all, p < 0.05), and the differences in the ACE2 SNPs rs4646142 and rs6632677 were correlated with COVID-19-related systemic inflammatory injury and cardiovascular risk. Specifically, rs4646142 was associated with high-sensitivity C-reactive protein (hs-CRP), prealbumin (PAB), apolipoprotein A (APOA), high-density lipoprotein (HDL), and acid glycoprotein (AGP) levels. Rs6632677 was also associated with elevated CRP, acid glycoprotein (AGP), and haptoglobin (HPT).
Conclusions: Our results suggest that the ACE2 SNPs rs4646142 and rs6632677 may be common genetic loci and optimal early identification genetic markers for COVID-19 with cardiovascular risk.
Keywords: ACE2; COVID-19; SNP; cardiovascular risks.