tetano
Editor, Senior Moderator
Pathophysiology
. 2022 Jun 1;29(2):233-242.
doi: 10.3390/pathophysiology29020019.
Platelet Distribution Width and Increased D-Dimer at Admission Predicts Subsequent Development of ARDS in COVID-19 Patients
Iviana P Yovchevska[SUP] 1 [/SUP], Alexandar B Trenovski[SUP] 2 [/SUP], Maria H Atanasova[SUP] 3 [/SUP], Martin N Georgiev[SUP] 4 [/SUP], Radka K Tafradjiiska-Hadjiolova[SUP] 1 [/SUP], Simeon D Lazarov[SUP] 1 [/SUP], Plamen H Yovchevski[SUP] 3 [/SUP]
Affiliations
Abstract
In the current pandemic of coronavirus disease (COVID-19), the identification of the patients admitted with severe infection-who are disposed to a high risk of acute respiratory distress syndrome (ARDS) development, is of a major significance for the determination of the appropriate therapeutic strategy. Laboratory records in admission were retrospectively reviewed from 493 cases of severe COVID-19 divided into two groups: Group 1 with ARDS and Group 2 without ARDS. The platelet distribution width (PDW) difference between Group 1 and Group 2 is significant-15.10 ± 2.08 fl for those who developed ARDS versus 12.94 ± 2.12 fl for those without ARDS. The sensitivity and the specificity of this parameter is lower than that of D-dimer. After grouping of the PDW values into intervals and combining them with the rate of increase in D-dimer (D-PDWf index) to form a forecasting index, a significant increase in the specificity and sensitivity of the two parameters is identified-area under the ROC curve (AUC) is 0.874 for D-PDWf index, with respective AUC for PDW 0.768 and AUC for D-dimer 0.777. Conclusion: PDW is a significant predictive parameter at admission for subsequent development of ARDS in patients, with increased significance in combination with the degree of increase in D-dimer.
Keywords: COVID-19; D-PDWf index; D-dimer; acute respiratory distress syndrome (ARDS); platelet distribution width.
. 2022 Jun 1;29(2):233-242.
doi: 10.3390/pathophysiology29020019.
Platelet Distribution Width and Increased D-Dimer at Admission Predicts Subsequent Development of ARDS in COVID-19 Patients
Iviana P Yovchevska[SUP] 1 [/SUP], Alexandar B Trenovski[SUP] 2 [/SUP], Maria H Atanasova[SUP] 3 [/SUP], Martin N Georgiev[SUP] 4 [/SUP], Radka K Tafradjiiska-Hadjiolova[SUP] 1 [/SUP], Simeon D Lazarov[SUP] 1 [/SUP], Plamen H Yovchevski[SUP] 3 [/SUP]
Affiliations
- PMID: 35736647
- DOI: 10.3390/pathophysiology29020019
Abstract
In the current pandemic of coronavirus disease (COVID-19), the identification of the patients admitted with severe infection-who are disposed to a high risk of acute respiratory distress syndrome (ARDS) development, is of a major significance for the determination of the appropriate therapeutic strategy. Laboratory records in admission were retrospectively reviewed from 493 cases of severe COVID-19 divided into two groups: Group 1 with ARDS and Group 2 without ARDS. The platelet distribution width (PDW) difference between Group 1 and Group 2 is significant-15.10 ± 2.08 fl for those who developed ARDS versus 12.94 ± 2.12 fl for those without ARDS. The sensitivity and the specificity of this parameter is lower than that of D-dimer. After grouping of the PDW values into intervals and combining them with the rate of increase in D-dimer (D-PDWf index) to form a forecasting index, a significant increase in the specificity and sensitivity of the two parameters is identified-area under the ROC curve (AUC) is 0.874 for D-PDWf index, with respective AUC for PDW 0.768 and AUC for D-dimer 0.777. Conclusion: PDW is a significant predictive parameter at admission for subsequent development of ARDS in patients, with increased significance in combination with the degree of increase in D-dimer.
Keywords: COVID-19; D-PDWf index; D-dimer; acute respiratory distress syndrome (ARDS); platelet distribution width.