tetano
Editor, Senior Moderator
Pediatr Neonatol
. 2021 May 14;S1875-9572(21)00082-6.
doi: 10.1016/j.pedneo.2021.05.002. Online ahead of print.
Clinical features and risk factors for severe influenza in children: A study from multiple hospitals in Shanghai
Yu Shi[SUP] 1 [/SUP], Weiming Chen[SUP] 2 [/SUP], Mei Zeng[SUP] 3 [/SUP], Guomei Shen[SUP] 4 [/SUP], Chengjun Sun[SUP] 5 [/SUP], Gongbao Liu[SUP] 6 [/SUP], Hairong Gong[SUP] 7 [/SUP], Chuanqing Wang[SUP] 8 [/SUP], Mengmeng Ge[SUP] 9 [/SUP], Jin Xu[SUP] 10 [/SUP], Libo Wang[SUP] 11 [/SUP], Aizhen Lu[SUP] 12 [/SUP], Guoping Lu[SUP] 13 [/SUP], Xiaowen Zhai[SUP] 14 [/SUP]
Affiliations
Abstract
Background: The incidence and mortality of influenza in children had risen, but data are limited on children with severe influenza virus infection in China.
Methods: We conducted a retrospective case-control study and collected the patients' clinical data. Clinical data including demography, clinical presentation, laboratory findings, radiologic findings, treatment and outcomes were collected. Children were clinically confirmed to have virus infection in Shanghai in three hospitals from June 2014 to June 2019.
Results: During the study, 36,047 children were enrolled. Among them, 118 met the criteria for severe flu. Clinical symptoms such as fever, cough, gastrointestinal symptoms, coma and epilepsy were higher in the severe group. Complications such as pneumorrhagia, heart failure, septic shock, acute renal failure and influenza-associated encephalitis were higher in the severe influenza group than the death group. The laboratory findings including decreased hemoglobin, high alanine aminotransferase, high urea nitrogen and high lactate levels were risk factors for death in children with influenza.
Conclusion: Influenza-associated encephalopathy (IAE), acute respiratory distress syndrome (ARDS) were the common clinical manifestations and complications for the severe influenza, and delayed use of oseltamivir was found to be associated with fatality.
Keywords: children; influenza; influenza-associated encephalitis; severe risks.
. 2021 May 14;S1875-9572(21)00082-6.
doi: 10.1016/j.pedneo.2021.05.002. Online ahead of print.
Clinical features and risk factors for severe influenza in children: A study from multiple hospitals in Shanghai
Yu Shi[SUP] 1 [/SUP], Weiming Chen[SUP] 2 [/SUP], Mei Zeng[SUP] 3 [/SUP], Guomei Shen[SUP] 4 [/SUP], Chengjun Sun[SUP] 5 [/SUP], Gongbao Liu[SUP] 6 [/SUP], Hairong Gong[SUP] 7 [/SUP], Chuanqing Wang[SUP] 8 [/SUP], Mengmeng Ge[SUP] 9 [/SUP], Jin Xu[SUP] 10 [/SUP], Libo Wang[SUP] 11 [/SUP], Aizhen Lu[SUP] 12 [/SUP], Guoping Lu[SUP] 13 [/SUP], Xiaowen Zhai[SUP] 14 [/SUP]
Affiliations
- PMID: 34103261
- DOI: 10.1016/j.pedneo.2021.05.002
Abstract
Background: The incidence and mortality of influenza in children had risen, but data are limited on children with severe influenza virus infection in China.
Methods: We conducted a retrospective case-control study and collected the patients' clinical data. Clinical data including demography, clinical presentation, laboratory findings, radiologic findings, treatment and outcomes were collected. Children were clinically confirmed to have virus infection in Shanghai in three hospitals from June 2014 to June 2019.
Results: During the study, 36,047 children were enrolled. Among them, 118 met the criteria for severe flu. Clinical symptoms such as fever, cough, gastrointestinal symptoms, coma and epilepsy were higher in the severe group. Complications such as pneumorrhagia, heart failure, septic shock, acute renal failure and influenza-associated encephalitis were higher in the severe influenza group than the death group. The laboratory findings including decreased hemoglobin, high alanine aminotransferase, high urea nitrogen and high lactate levels were risk factors for death in children with influenza.
Conclusion: Influenza-associated encephalopathy (IAE), acute respiratory distress syndrome (ARDS) were the common clinical manifestations and complications for the severe influenza, and delayed use of oseltamivir was found to be associated with fatality.
Keywords: children; influenza; influenza-associated encephalitis; severe risks.