tetano
Editor, Senior Moderator
Pediatr Res
. 2020 Jun 17.
doi: 10.1038/s41390-020-1015-2. Online ahead of print.
Coronavirus Disease 2019 (COVID-19) in Children and/or Adolescents: A Meta-Analysis
Alessandro Mantovani[SUP] 1 [/SUP], Elisabetta Rinaldi[SUP] 2 [/SUP], Chiara Zusi[SUP] 2 3 [/SUP], Giorgia Beatrice[SUP] 2 [/SUP], Marco Deganello Saccomani[SUP] 4 [/SUP], Andrea Dalbeni[SUP] 5 [/SUP]
Affiliations
Abstract
Background: To assess the overall prevalence of clinical signs, symptoms, and radiological findings in children and/or adolescents with COVID-19.
Methods: We systematically researched in PubMed, Scopus and Web of Science databases observational studies describing COVID-19 in children and/or adolescents until April 11, 2020. Data regarding clinical and radiological features were extracted from eligible studies and meta-analysis was performed using random-effects modeling.
Results: We examined 19 eligible studies for a total of 2855 children and/or adolescents with COVID-19. Approximately 47% of subjects had fever (95% confidence interval [CI] 22-72%; I[SUP]2[/SUP] = 98.6%), 37% cough (95%CI 15-63%; I[SUP]2[/SUP] = 98.6%), 4% diarrhea (95%CI 0-12%; I[SUP]2[/SUP] = 92.2%), 2% nasal congestion (95%CI 0-7%; I[SUP]2[/SUP] = 87.7%), 1% dyspnea (95%CI 0-7%; I[SUP]2[/SUP] = 91.5%) and 0% abdominal pain (95%CI 0-1%; I[SUP]2[/SUP] = 76.3%). Subjects presented mild symptoms in 79% (95%CI 65-91%; I[SUP]2[/SUP] = 93.5%) of cases, whereas only 4% (95%CI 1-9%; I[SUP]2[/SUP] = 76.4%) were critical. Among those with pneumonia on computed tomography, 26.4% (95%CI 13-41%; I[SUP]2[/SUP] = 80.8%) presented a unilateral involvement, 16% (95%CI 5-29%, I[SUP]2[/SUP] = 81.2%) had bilateral involvement and 9% (95%CI 0-24%; I[SUP]2[/SUP] = 88.7%) had interstitial pneumonia.
Conclusions: Children and/or adolescents tend to have a mild COVID-19 course with a good prognosis.
Impact: Compared to adults, children and/or adolescents tend to have a mild COVID-19 course with a good prognosis. This study provides new and consistence information on the clinical and radiological characteristics of COVID-19 in pediatrics. This study may help to fight COVID-19 in pediatric population.
. 2020 Jun 17.
doi: 10.1038/s41390-020-1015-2. Online ahead of print.
Coronavirus Disease 2019 (COVID-19) in Children and/or Adolescents: A Meta-Analysis
Alessandro Mantovani[SUP] 1 [/SUP], Elisabetta Rinaldi[SUP] 2 [/SUP], Chiara Zusi[SUP] 2 3 [/SUP], Giorgia Beatrice[SUP] 2 [/SUP], Marco Deganello Saccomani[SUP] 4 [/SUP], Andrea Dalbeni[SUP] 5 [/SUP]
Affiliations
- PMID: 32555539
- DOI: 10.1038/s41390-020-1015-2
Abstract
Background: To assess the overall prevalence of clinical signs, symptoms, and radiological findings in children and/or adolescents with COVID-19.
Methods: We systematically researched in PubMed, Scopus and Web of Science databases observational studies describing COVID-19 in children and/or adolescents until April 11, 2020. Data regarding clinical and radiological features were extracted from eligible studies and meta-analysis was performed using random-effects modeling.
Results: We examined 19 eligible studies for a total of 2855 children and/or adolescents with COVID-19. Approximately 47% of subjects had fever (95% confidence interval [CI] 22-72%; I[SUP]2[/SUP] = 98.6%), 37% cough (95%CI 15-63%; I[SUP]2[/SUP] = 98.6%), 4% diarrhea (95%CI 0-12%; I[SUP]2[/SUP] = 92.2%), 2% nasal congestion (95%CI 0-7%; I[SUP]2[/SUP] = 87.7%), 1% dyspnea (95%CI 0-7%; I[SUP]2[/SUP] = 91.5%) and 0% abdominal pain (95%CI 0-1%; I[SUP]2[/SUP] = 76.3%). Subjects presented mild symptoms in 79% (95%CI 65-91%; I[SUP]2[/SUP] = 93.5%) of cases, whereas only 4% (95%CI 1-9%; I[SUP]2[/SUP] = 76.4%) were critical. Among those with pneumonia on computed tomography, 26.4% (95%CI 13-41%; I[SUP]2[/SUP] = 80.8%) presented a unilateral involvement, 16% (95%CI 5-29%, I[SUP]2[/SUP] = 81.2%) had bilateral involvement and 9% (95%CI 0-24%; I[SUP]2[/SUP] = 88.7%) had interstitial pneumonia.
Conclusions: Children and/or adolescents tend to have a mild COVID-19 course with a good prognosis.
Impact: Compared to adults, children and/or adolescents tend to have a mild COVID-19 course with a good prognosis. This study provides new and consistence information on the clinical and radiological characteristics of COVID-19 in pediatrics. This study may help to fight COVID-19 in pediatric population.