tetano
Editor, Senior Moderator
PLoS One
. 2020 Jun 17;15(6):e0234764.
doi: 10.1371/journal.pone.0234764. eCollection 2020.
Clinical Characteristics of Coronavirus Disease 2019 Patients in Beijing, China
Zhenhuan Cao[SUP] 1 [/SUP], Tongzeng Li[SUP] 1 [/SUP], Lianchun Liang[SUP] 1 [/SUP], Haibo Wang[SUP] 2 [/SUP], Feili Wei[SUP] 3 [/SUP], Sha Meng[SUP] 4 [/SUP], Miaotian Cai[SUP] 1 [/SUP], Yulong Zhang[SUP] 1 [/SUP], Hui Xu[SUP] 1 [/SUP], Jiaying Zhang[SUP] 1 [/SUP], Ronghua Jin[SUP] 1 [/SUP]
Affiliations
Abstract
The outbreak of Coronavirus Disease (COVID-19) in Wuhan have affected more than 250 countries and regions worldwide. However, most of the clinical studies have been focused on Wuhan, and little is known about the disease outside of Wuhan in China. In this retrospective cohort study, we report the early clinical features of 80 patients with COVID-19 admitted to the hospital in Beijing. The results show that 27 (33.8%) patients had severe illness. Six (7.5%) patients were admitted to the ICU, and 3 (3.8%) patients died. Forty-eight percent (39/80) of the patients had a history of living/traveling in Wuhan. Patients with severe- illness were significantly older (average age, 71 years old vs 44 years old) and had a high incidence of expectoration (59.3% vs 34.0%), shortness of breath (92.6% vs 9.4%), anorexia (51.9% vs 18.9%) and confusion(18.5% vs 0%) compared with nonsevere patients. The systolic blood pressure (median, 130 mmHg vs 120 mmHg) was higher and the oxygen saturation (median, 98.3% vs 92.0%) was significantly lower in severe patients than nonsevere patients. In addition, myoglobin (median, 56.0 ng/mL vs 35.0 ng/mL), troponin I (median, 0.02 pg/mL vs 0.01 pg/mL), C-reactive protein (median, 69.7 mg/L vs 12.9 mg/L) and neutrophils (median, 3.3?109/L vs 2.2?109/L) were significantly increased, while lymphocytes (median, 0.8?109/L vs 1.2?109/L), albumin (mean, 32.8 g/L vs 36.8 g/L) and the creatinine clearance rate (median, 91.2 vs 108.2 ml/min/1.73m2) were significantly decreased among severe patients. Our study revealed that older patients with high levels of C-reactive protein, myoglobin, troponin I, and neutrophil and high systolic blood pressure as well as low levels of lymphocytes, and albumin and a low creatinine clearance rate and oxygen saturation were more likely to have severe disease.
. 2020 Jun 17;15(6):e0234764.
doi: 10.1371/journal.pone.0234764. eCollection 2020.
Clinical Characteristics of Coronavirus Disease 2019 Patients in Beijing, China
Zhenhuan Cao[SUP] 1 [/SUP], Tongzeng Li[SUP] 1 [/SUP], Lianchun Liang[SUP] 1 [/SUP], Haibo Wang[SUP] 2 [/SUP], Feili Wei[SUP] 3 [/SUP], Sha Meng[SUP] 4 [/SUP], Miaotian Cai[SUP] 1 [/SUP], Yulong Zhang[SUP] 1 [/SUP], Hui Xu[SUP] 1 [/SUP], Jiaying Zhang[SUP] 1 [/SUP], Ronghua Jin[SUP] 1 [/SUP]
Affiliations
- PMID: 32555674
- DOI: 10.1371/journal.pone.0234764
Abstract
The outbreak of Coronavirus Disease (COVID-19) in Wuhan have affected more than 250 countries and regions worldwide. However, most of the clinical studies have been focused on Wuhan, and little is known about the disease outside of Wuhan in China. In this retrospective cohort study, we report the early clinical features of 80 patients with COVID-19 admitted to the hospital in Beijing. The results show that 27 (33.8%) patients had severe illness. Six (7.5%) patients were admitted to the ICU, and 3 (3.8%) patients died. Forty-eight percent (39/80) of the patients had a history of living/traveling in Wuhan. Patients with severe- illness were significantly older (average age, 71 years old vs 44 years old) and had a high incidence of expectoration (59.3% vs 34.0%), shortness of breath (92.6% vs 9.4%), anorexia (51.9% vs 18.9%) and confusion(18.5% vs 0%) compared with nonsevere patients. The systolic blood pressure (median, 130 mmHg vs 120 mmHg) was higher and the oxygen saturation (median, 98.3% vs 92.0%) was significantly lower in severe patients than nonsevere patients. In addition, myoglobin (median, 56.0 ng/mL vs 35.0 ng/mL), troponin I (median, 0.02 pg/mL vs 0.01 pg/mL), C-reactive protein (median, 69.7 mg/L vs 12.9 mg/L) and neutrophils (median, 3.3?109/L vs 2.2?109/L) were significantly increased, while lymphocytes (median, 0.8?109/L vs 1.2?109/L), albumin (mean, 32.8 g/L vs 36.8 g/L) and the creatinine clearance rate (median, 91.2 vs 108.2 ml/min/1.73m2) were significantly decreased among severe patients. Our study revealed that older patients with high levels of C-reactive protein, myoglobin, troponin I, and neutrophil and high systolic blood pressure as well as low levels of lymphocytes, and albumin and a low creatinine clearance rate and oxygen saturation were more likely to have severe disease.