tetano
Editor, Senior Moderator
PLoS One
. 2022 Feb 9;17(2):e0261980.
doi: 10.1371/journal.pone.0261980. eCollection 2022.
Hydroxychloroquine for prophylaxis of COVID-19 in health workers: A randomized clinical trial
Jorge Rojas-Serrano[SUP] 1 [/SUP], Angelica Margarita Portillo-Vásquez[SUP] 2 [/SUP], Ireri Thirion-Romero[SUP] 3 [/SUP], Joel Vázquez-Pérez[SUP] 3 [/SUP], Fidencio Mejía-Nepomuceno[SUP] 3 [/SUP], Alejandra Ramírez-Venegas[SUP] 3 [/SUP], Karla Midori Pérez-Kawabe[SUP] 3 [/SUP], Rogelio Pérez-Padilla[SUP] 3 [/SUP]
Affiliations
Abstract
Introduction: Health care workers are at high risk of being infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our aim is to evaluate the efficacy and safety of hydroxychloroquine (HCQ) for prophylaxis of coronavirus disease 19 (COVID-19) in health personnel exposed to patients infected by SARS-CoV-2.
Methods: Double-blind randomized, placebo-controlled single center clinical trial. Included subjects were health care workers caring for severe COVID-19 patients. Main outcome was time to symptomatic SARS-CoV-2 infection.
Results: 127 subjects with a confirmed baseline negative RT-PCR SARS-CoV2 test were included in the trial. 62 assigned to HCQ and 65 to placebo. One subject (1.6%) in the HCQ group and 6 (9.2%) subjects in the placebo group developed COVID-19 (Log-Rank test p = 0.07). No severe COVID-19 cases were observed. The study was suspended because of a refusal to participate and losses to follow up after several trials reported lack of effectiveness of hydroxychloroquine in hospitalized patients with COVID-19.
Conclusion: The effect size of hydroxychloroquine was higher than placebo for COVID-19 symptomatic infection in health personnel, although this was not statistically significant. The trial is underpowered due to the failure to complete the estimated sample size.
. 2022 Feb 9;17(2):e0261980.
doi: 10.1371/journal.pone.0261980. eCollection 2022.
Hydroxychloroquine for prophylaxis of COVID-19 in health workers: A randomized clinical trial
Jorge Rojas-Serrano[SUP] 1 [/SUP], Angelica Margarita Portillo-Vásquez[SUP] 2 [/SUP], Ireri Thirion-Romero[SUP] 3 [/SUP], Joel Vázquez-Pérez[SUP] 3 [/SUP], Fidencio Mejía-Nepomuceno[SUP] 3 [/SUP], Alejandra Ramírez-Venegas[SUP] 3 [/SUP], Karla Midori Pérez-Kawabe[SUP] 3 [/SUP], Rogelio Pérez-Padilla[SUP] 3 [/SUP]
Affiliations
- PMID: 35139097
- DOI: 10.1371/journal.pone.0261980
Abstract
Introduction: Health care workers are at high risk of being infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our aim is to evaluate the efficacy and safety of hydroxychloroquine (HCQ) for prophylaxis of coronavirus disease 19 (COVID-19) in health personnel exposed to patients infected by SARS-CoV-2.
Methods: Double-blind randomized, placebo-controlled single center clinical trial. Included subjects were health care workers caring for severe COVID-19 patients. Main outcome was time to symptomatic SARS-CoV-2 infection.
Results: 127 subjects with a confirmed baseline negative RT-PCR SARS-CoV2 test were included in the trial. 62 assigned to HCQ and 65 to placebo. One subject (1.6%) in the HCQ group and 6 (9.2%) subjects in the placebo group developed COVID-19 (Log-Rank test p = 0.07). No severe COVID-19 cases were observed. The study was suspended because of a refusal to participate and losses to follow up after several trials reported lack of effectiveness of hydroxychloroquine in hospitalized patients with COVID-19.
Conclusion: The effect size of hydroxychloroquine was higher than placebo for COVID-19 symptomatic infection in health personnel, although this was not statistically significant. The trial is underpowered due to the failure to complete the estimated sample size.