tetano
Editor, Senior Moderator
PLoS One
. 2021 May 6;16(5):e0251234.
doi: 10.1371/journal.pone.0251234. eCollection 2021.
Seroepidemiological study of SARS-CoV-2 infection in East Java, Indonesia
Ni Luh Ayu Megasari[SUP] 1 [/SUP], Takako Utsumi[SUP] 1 2 [/SUP], Laura Navika Yamani[SUP] 1 3 [/SUP], Juniastuti[SUP] 1 [/SUP], Emily Gunawan[SUP] 1 [/SUP], Koichi Furukawa[SUP] 2 [/SUP], Mitsuhiro Nishimura[SUP] 2 [/SUP], Maria Inge Lusida[SUP] 1 [/SUP], Yasuko Mori[SUP] 2 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global pandemic, including Indonesia. However, there are only limited data regarding the precise prevalence of the COVID-19 pandemic in Indonesia. Here, to estimate the magnitude of SARS-CoV-2 infection in East Java, Indonesia, we investigated the prevalence of immunoglobulin G (IgG) antibodies. We enrolled 1,819 individuals from June to December 2020 and observed that the subjects' overall prevalence of IgG antibody to SARS-CoV-2 was 11.4% (207/1,819). The prevalence of anti-SARS-CoV-2 antibodies differed significantly between the job/occupation groups (P = 0.0001). A greater prevalence of IgG was detected in laboratory technicians (who take samples from suspected cases and deal with polymerase chain reaction [PCR] procedures, 22.2%) compared to medical personnel who see and take direct care of patients with COVID-19 (e.g., physicians and nurses, 6.0%), other staff in medical facilities (2.9%), general population (12.1%) and non-COVID-19 patients (14.6%). The highest prevalence among age groups was in the 40-49-year-olds (14.8%), and the lowest prevalence was in the 20-29-year-olds (7.4%). However, the younger population still showed a higher prevalence than generally reported, suggesting greater exposure to the virus but less susceptibility to the disease. A geographical difference was also observed: a higher prevalence in Surabaya (13.1%) than in Jombang (9.9%). In conclusion, the COVID-19 outbreak among asymptomatic populations was characterized by a high prevalence of infection in East Java, Indonesia.
. 2021 May 6;16(5):e0251234.
doi: 10.1371/journal.pone.0251234. eCollection 2021.
Seroepidemiological study of SARS-CoV-2 infection in East Java, Indonesia
Ni Luh Ayu Megasari[SUP] 1 [/SUP], Takako Utsumi[SUP] 1 2 [/SUP], Laura Navika Yamani[SUP] 1 3 [/SUP], Juniastuti[SUP] 1 [/SUP], Emily Gunawan[SUP] 1 [/SUP], Koichi Furukawa[SUP] 2 [/SUP], Mitsuhiro Nishimura[SUP] 2 [/SUP], Maria Inge Lusida[SUP] 1 [/SUP], Yasuko Mori[SUP] 2 [/SUP]
Affiliations
- PMID: 33956869
- DOI: 10.1371/journal.pone.0251234
Abstract
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global pandemic, including Indonesia. However, there are only limited data regarding the precise prevalence of the COVID-19 pandemic in Indonesia. Here, to estimate the magnitude of SARS-CoV-2 infection in East Java, Indonesia, we investigated the prevalence of immunoglobulin G (IgG) antibodies. We enrolled 1,819 individuals from June to December 2020 and observed that the subjects' overall prevalence of IgG antibody to SARS-CoV-2 was 11.4% (207/1,819). The prevalence of anti-SARS-CoV-2 antibodies differed significantly between the job/occupation groups (P = 0.0001). A greater prevalence of IgG was detected in laboratory technicians (who take samples from suspected cases and deal with polymerase chain reaction [PCR] procedures, 22.2%) compared to medical personnel who see and take direct care of patients with COVID-19 (e.g., physicians and nurses, 6.0%), other staff in medical facilities (2.9%), general population (12.1%) and non-COVID-19 patients (14.6%). The highest prevalence among age groups was in the 40-49-year-olds (14.8%), and the lowest prevalence was in the 20-29-year-olds (7.4%). However, the younger population still showed a higher prevalence than generally reported, suggesting greater exposure to the virus but less susceptibility to the disease. A geographical difference was also observed: a higher prevalence in Surabaya (13.1%) than in Jombang (9.9%). In conclusion, the COVID-19 outbreak among asymptomatic populations was characterized by a high prevalence of infection in East Java, Indonesia.