Giuseppe
Emeritus
[Source: PLoS ONE, full text: (LINK). Abstract, edited.]
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Successful Control of Methicillin-Resistant Staphylococcus aureus in Endemic Neonatal Intensive Care Units—A 7-Year Campaign
Yhu-Chering Huang<SUP>1</SUP><SUP>,</SUP><SUP>3</SUP><SUP>,</SUP><SUP>5</SUP><SUP>*</SUP>, Rey-In Lien<SUP>2</SUP><SUP>,</SUP><SUP>5</SUP>, Lin-Hui Su<SUP>3</SUP><SUP>,</SUP><SUP>4</SUP><SUP>,</SUP><SUP>5</SUP>, Yi-Hong Chou<SUP>2</SUP>, Tzou-Yien Lin<SUP>1</SUP><SUP>,</SUP><SUP>3</SUP><SUP>,</SUP><SUP>5</SUP>
1 Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital at Linkou, Kweishan, Taoyuan, Taiwan, 2 Division of Neonatology, Chang Gung Memorial Hospital at Linkou, Kweishan, Taoyuan, Taiwan, 3 Committee of Infection Control, Chang Gung Memorial Hospital at Linkou, Kweishan, Taoyuan, Taiwan, 4 Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Kweishan, Taoyuan, Taiwan, 5 School of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan
Abstract
Background
Methicillin-resistant Staphylococcus aureus (MRSA) is among the most important nosocomial pathogens in the intensive care unit (ICU) worldwide, including Taiwan. Since 1997, our neonatal ICUs (NICUs) had become endemic for MRSA.
Methodology/Principal Findings
To control MRSA spread in our NICUs, we implemented a series of infection control measures stepwise, including reinforcement of hand hygiene since January 2000, augmentation of aseptic care over the insertion site of central venous catheter since July 2001, introduction of alcohol-based handrubs since April 2003, surveillance culture for MRSA and cohort care for the colonized patients between March 2003 and February 2004, and surveillance culture with subsequent decolonization of MRSA between August 2005 and July 2006. After implementation of these measures, MRSA healthcare-associated infection (HAI) density reduced by 92%, from 5.47 episodes per 1000 patient-days in 1999 to 0.45 episodes per 1000 patient-days in 2006; MRSA bloodstream infection reduced from 40 cases in 1999 to only one case in 2006. Compared to those obtained during the period of surveillance culture without decolonization, both rates of MRSA colonization (8.6% vs. 41%, p<0.001) and infection (1.1% vs. 12%, p<0.001) decreased significantly during the period of surveillance and decolonization. Molecular analysis of the clinical isolates during the study period showed that the endemic clone, which dominated between 1998 and 2005, almost disappeared in 2006, while the community clones increased significantly in 2006–2007.
Conclusion/Significance
Through infection control measures, MRSA HAIs can be successfully controlled, even in areas with high levels of endemic MRSA infections such as our NICUs.
Citation: Huang Y-C, Lien R-I, Su L-H, Chou Y-H, Lin T-Y (2011) Successful Control of Methicillin-Resistant Staphylococcus aureus in Endemic Neonatal Intensive Care Units—A 7-Year Campaign. PLoS ONE 6(8): e23001. doi:10.1371/journal.pone.0023001
Editor: Sarah K. Highlander, Baylor College of Medicine, United States of America
Received: April 20, 2011; Accepted: July 5, 2011; Published: August 12, 2011
Copyright: © 2011 Huang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This study was supported by grants from the National Science Council (NSC 94-2314-B-182A-090, 96-2314-B-182A-022) and Chang Gung Memorial Hospital (CMRPG 33128). The funders had no role in study design, data collection and analysis, decision to publish.
Competing interests: The authors have declared that no competing interests exist.
* E-mail: ychuang@cgmh.org.tw
-Yhu-Chering Huang<SUP>1</SUP><SUP>,</SUP><SUP>3</SUP><SUP>,</SUP><SUP>5</SUP><SUP>*</SUP>, Rey-In Lien<SUP>2</SUP><SUP>,</SUP><SUP>5</SUP>, Lin-Hui Su<SUP>3</SUP><SUP>,</SUP><SUP>4</SUP><SUP>,</SUP><SUP>5</SUP>, Yi-Hong Chou<SUP>2</SUP>, Tzou-Yien Lin<SUP>1</SUP><SUP>,</SUP><SUP>3</SUP><SUP>,</SUP><SUP>5</SUP>
1 Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital at Linkou, Kweishan, Taoyuan, Taiwan, 2 Division of Neonatology, Chang Gung Memorial Hospital at Linkou, Kweishan, Taoyuan, Taiwan, 3 Committee of Infection Control, Chang Gung Memorial Hospital at Linkou, Kweishan, Taoyuan, Taiwan, 4 Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Kweishan, Taoyuan, Taiwan, 5 School of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan
Abstract
Background
Methicillin-resistant Staphylococcus aureus (MRSA) is among the most important nosocomial pathogens in the intensive care unit (ICU) worldwide, including Taiwan. Since 1997, our neonatal ICUs (NICUs) had become endemic for MRSA.
Methodology/Principal Findings
To control MRSA spread in our NICUs, we implemented a series of infection control measures stepwise, including reinforcement of hand hygiene since January 2000, augmentation of aseptic care over the insertion site of central venous catheter since July 2001, introduction of alcohol-based handrubs since April 2003, surveillance culture for MRSA and cohort care for the colonized patients between March 2003 and February 2004, and surveillance culture with subsequent decolonization of MRSA between August 2005 and July 2006. After implementation of these measures, MRSA healthcare-associated infection (HAI) density reduced by 92%, from 5.47 episodes per 1000 patient-days in 1999 to 0.45 episodes per 1000 patient-days in 2006; MRSA bloodstream infection reduced from 40 cases in 1999 to only one case in 2006. Compared to those obtained during the period of surveillance culture without decolonization, both rates of MRSA colonization (8.6% vs. 41%, p<0.001) and infection (1.1% vs. 12%, p<0.001) decreased significantly during the period of surveillance and decolonization. Molecular analysis of the clinical isolates during the study period showed that the endemic clone, which dominated between 1998 and 2005, almost disappeared in 2006, while the community clones increased significantly in 2006–2007.
Conclusion/Significance
Through infection control measures, MRSA HAIs can be successfully controlled, even in areas with high levels of endemic MRSA infections such as our NICUs.
Citation: Huang Y-C, Lien R-I, Su L-H, Chou Y-H, Lin T-Y (2011) Successful Control of Methicillin-Resistant Staphylococcus aureus in Endemic Neonatal Intensive Care Units—A 7-Year Campaign. PLoS ONE 6(8): e23001. doi:10.1371/journal.pone.0023001
Editor: Sarah K. Highlander, Baylor College of Medicine, United States of America
Received: April 20, 2011; Accepted: July 5, 2011; Published: August 12, 2011
Copyright: © 2011 Huang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This study was supported by grants from the National Science Council (NSC 94-2314-B-182A-090, 96-2314-B-182A-022) and Chang Gung Memorial Hospital (CMRPG 33128). The funders had no role in study design, data collection and analysis, decision to publish.
Competing interests: The authors have declared that no competing interests exist.
* E-mail: ychuang@cgmh.org.tw
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