tetano
Editor, Senior Moderator
Vopr Virusol. 2011 Nov-Dec;56(6):19-22.
[Preclinical studies of live intranasal H5N1 influenza vaccine with the deleted HS1 gene].
[Article in Russian]
[No authors listed]
Abstract
The paper gives the results of evaluating the efficiency of deINS1 pandemic H5N1 vaccine candidate VN1203delNS1 which was constructed by reverse genetics on the basis of influenza virus strain A/Vietnam/1203/04. The safety, immunogenicity and cross-protection of the vaccine strain against different H5N1 virus clades were demonstrated in mouse and macaque models. The results showed the possibility of designing a new-generation replication-deficient intranasal influenza vaccine, by applying an approach to deleting the NS1 pathogenicity factor, an antagonist of the interferon system.
PMID:
22359944
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22359944
[Preclinical studies of live intranasal H5N1 influenza vaccine with the deleted HS1 gene].
[Article in Russian]
[No authors listed]
Abstract
The paper gives the results of evaluating the efficiency of deINS1 pandemic H5N1 vaccine candidate VN1203delNS1 which was constructed by reverse genetics on the basis of influenza virus strain A/Vietnam/1203/04. The safety, immunogenicity and cross-protection of the vaccine strain against different H5N1 virus clades were demonstrated in mouse and macaque models. The results showed the possibility of designing a new-generation replication-deficient intranasal influenza vaccine, by applying an approach to deleting the NS1 pathogenicity factor, an antagonist of the interferon system.
PMID:
22359944
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22359944